Irbesartan/Hydrochloorthiazide Aurobindo

Irbesartan, the active ingredient in Irbesartan/Hydrochloorthiazide Aurobindo, is an Angiotensin II receptor blocker presented as an oral tablet for oral use. It treats hypertension in adult patients by lowering elevated blood pressure.

GNH USA supplies Irbesartan/Hydrochloorthiazide Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Irbesartan/Hydrochlorothiazide is used to manage hypertension, a condition characterized by chronically elevated arterial pressure.

- Hypertension: reduces systolic and diastolic blood pressure, helping to prevent cardiovascular complications.

The combination may cause a range of adverse reactions, which are grouped by frequency.

Common Side Effects: - Dizziness or light‑headedness - Headache - Increased urination or nocturia - Electrolyte disturbances such as low potassium - Fatigue or weakness

Serious or Rare Side Effects: - Severe dehydration or electrolyte imbalance - Acute kidney injury or worsening renal function - Anaphylactic or severe allergic reactions

When prescribing Irbesartan/Hydrochlorothiazide, clinicians should observe several safety considerations.

- Blood pressure monitoring: check regularly to avoid hypotension. - Renal function assessment: evaluate serum creatinine and eGFR before and during therapy. - Electrolyte balance: monitor potassium and sodium levels due to the diuretic component. - Use caution in pregnancy: limited data; avoid unless benefit outweighs risk. - Drug interactions: review concomitant medications for potential interactions. - Store at room temperature: keep in original packaging, protect from moisture and light.

Irbesartan/Hydrochlorothiazide can interact with several medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid): - Aliskiren: combined use may increase risk of renal impairment and hyperkalemia. - Potassium‑sparing diuretics (e.g., spironolactone): may cause dangerous hyperkalemia. - ACE inhibitors or other ARBs: additive effect on potassium and renal function.

Moderate Interactions (Monitor Closely): - NSAIDs (e.g., ibuprofen): may blunt antihypertensive effect and affect renal function. - Lithium: increased lithium levels can lead to toxicity. - Other antihypertensives (e.g., beta‑blockers): may enhance blood‑pressure lowering, requiring dose adjustment.