Irbesartan + Hidroclorotiazida Beapy Bluemed Unipessoal, Lda

Irbesartan, the active ingredient in Irbesartan + Hydrochlorothiazide, is an Angiotensin II receptor blocker presented as a combined tablet for oral use. It is employed to lower blood pressure in adults with essential hypertension, often when additional control beyond monotherapy is required.

GNH USA supplies Irbesartan + Hydrochlorothiazide as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance through its global distribution network. The company adheres to stringent manufacturing standards and provides reliable logistics for timely delivery to healthcare providers.

Irbesartan/Hydrochlorothiazide is an antihypertensive combination that lowers blood pressure by blocking the renin‑angiotensin system and enhancing diuresis.

Essential hypertension: reduces systolic and diastolic pressure in patients with primary high blood pressure. Resistant hypertension: provides additional blood‑pressure control when a single agent is insufficient. Hypertension with fluid retention: helps manage blood pressure while decreasing excess extracellular fluid.

Like all antihypertensive agents, Irbesartan/Hydrochlorothiazide may cause adverse reactions, which are classified by frequency and severity.

Common Side Effects: - Dizziness - Headache - Increased urination

Serious or Rare Side Effects: - Severe dehydration - Acute kidney injury - Angioedema

Precautions for Irbesartan/Hydrochlorothiazide focus on renal function, electrolyte balance, and specific patient populations.

Monitor renal function: assess serum creatinine and eGFR before initiation and periodically during therapy. Check electrolytes: watch for sodium and potassium abnormalities, especially hypokalemia. Avoid use in pregnancy: contraindicated in the second and third trimesters due to fetal risk. Use cautiously in elderly: increased susceptibility to hypotension and electrolyte shifts. Review concomitant medications: NSAIDs, lithium, and other diuretics may amplify adverse effects. Store at ambient temperature: keep tablets in original container, protect from moisture and light.

Irbesartan/Hydrochlorothiazide can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid): - ACE inhibitor or ARB combination: risk of hyperkalemia and renal dysfunction. - Potassium‑sparing diuretics: may cause dangerous potassium elevation. - Lithium: increased lithium concentrations leading to toxicity.

Moderate Interactions (Monitor Closely): - NSAIDs: can reduce antihypertensive effect and affect kidney function. - CYP2C9 inhibitors (e.g., fluconazole): may raise irbesartan levels.