Irbesartan E Idroclorotiazide Eg

Irbesartan, the active ingredient in Irbesartan E Idroclorotiazide Eg, is a angiotensin II receptor blocker (ARB) presented as a tablet for oral use. It is combined with hydrochlorothiazide to treat hypertension in adults.

GNH USA supplies Irbesartan E Idroclorotiazide Eg as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Irbesartan/Hydrochlorothiazide is used to manage hypertension, a condition characterized by elevated blood pressure.

- Primary hypertension: lowers both systolic and diastolic pressure through vasodilation and diuresis. - Secondary hypertension: assists in controlling blood pressure when it results from another underlying disorder. - Hypertension with fluid retention: combines vasodilatory and diuretic actions to improve overall blood pressure control.

Common Side Effects: - Dizziness: feeling light‑headed, especially after standing. - Headache: mild to moderate pain in the head region. - Increased urination: more frequent need to void due to diuretic action. - Electrolyte imbalance (low potassium): mild reductions in serum potassium levels.

Serious or Rare Side Effects: - Severe dehydration: excessive fluid loss leading to low blood pressure. - Acute kidney injury: sudden decline in renal function. - Allergic reaction: rash, itching, swelling, or difficulty breathing. - Hyperkalemia: elevated potassium levels, potentially causing cardiac arrhythmia. - Severe hypotension: markedly low blood pressure requiring medical attention.

Before initiating therapy, consider the following precautions: - Renal function monitoring: assess serum creatinine and eGFR regularly. - Electrolyte surveillance: check potassium and sodium levels periodically. - Hepatic impairment: use with caution in patients with liver disease. - Severe hypotension: avoid in individuals with markedly low blood pressure. - Pregnancy and lactation: safety not established; consult a specialist. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Irbesartan/Hydrochlorothiazide may interact with several medicines:

Major Interactions (Avoid): - Aliskiren: combined use can increase risk of renal dysfunction and hyperkalemia. - Potassium‑sparing diuretics or supplements: may cause dangerous hyperkalemia. - Lithium: increased lithium levels leading to toxicity. - ACE inhibitors or other ARBs: additive effects on potassium and renal function. - NSAIDs (high dose): can reduce antihypertensive efficacy and impair renal function.

Moderate Interactions (Monitor Closely): - Antidiabetic agents: diuretic may affect glucose control, requiring dose adjustment. - Other antihypertensives: additive blood pressure lowering effect. - CYP2C9 inhibitors (e.g., fluconazole): may increase irbesartan plasma concentrations. - Thiazide‑type diuretics: overlapping diuretic effect may increase electrolyte disturbances. - Antacids containing aluminum or magnesium: may reduce absorption of irbesartan.