GNH USA

Europe — EMA

Irbesartan Crescent Pharma

GNH USA supplies Irbesartan Crescent Pharma (Irbesartan), a angiotensin II receptor blocker for hypertension, diabetic nephropathy and heart failure.

Irbesartan

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What is Irbesartan?

Irbesartan, the active ingredient in Irbesartan Crescent Pharma, is an angiotensin II receptor blocker presented as a tablet for oral use. It lowers blood pressure and is prescribed for adults with hypertension and related cardiovascular conditions.

GNH USA supplies Irbesartan Crescent Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Irbesartan used for?

Irbesartan is used to manage conditions that involve the renin‑angiotensin system.

- Hypertension: Reduces systolic and diastolic blood pressure, helping to prevent cardiovascular complications. - Diabetic nephropathy: Slows progression of kidney damage in patients with type 2 diabetes. - Heart failure: Improves symptoms and reduces hospitalisation risk in patients with reduced‑ejection‑fraction heart failure.

What are the side effects of Irbesartan?

Irbesartan may cause a range of adverse reactions, which are classified by frequency.

Common Side Effects: - Dizziness - Headache - Fatigue

Serious or Rare Side Effects: - Hyperkalemia - Acute kidney injury - Angio‑edema

What precautions apply to Irbesartan?

When prescribing Irbesartan, clinicians should consider several safety measures.

- Monitor blood pressure: Check regularly to ensure therapeutic effect. - Assess renal function: Evaluate serum creatinine and eGFR before and during therapy. - Check electrolytes: Particularly potassium levels, especially in patients on potassium‑sparing diuretics. - Avoid in severe hepatic impairment: Use with caution or not at all. - Pregnancy: Do not use during the second and third trimesters; consult obstetric guidance. - Store at room temperature: Keep below 25 °C, in the original container, protected from moisture and light.

What does Irbesartan interact with?

Irbesartan can interact with several drug classes, requiring attention to avoid harmful effects.

Major Interactions (Avoid): - Concomitant use with aliskiren in diabetic patients: Increases risk of renal impairment. - Potassium‑supplementing agents or potassium‑sparing diuretics: May cause dangerous hyperkalemia. - Dual renin‑angiotensin system blockade (e.g., ACE inhibitors): Heightens risk of hypotension and renal dysfunction.

Moderate Interactions (Monitor Closely): - NSAIDs (ibuprofen, naproxen): Can reduce antihypertensive effect and affect kidney function. - Lithium: May increase lithium levels, risking toxicity. - Diuretics (thiazides): May enhance hypotensive effect; monitor blood pressure.

Frequently asked questions

What is Irbesartan Crescent Pharma used for?+
Irbesartan Crescent Pharma is an oral angiotensin II receptor blocker indicated for the treatment of hypertension, diabetic nephropathy, and heart failure. It helps lower blood pressure and protect kidney function in patients with type 2 diabetes, while also improving symptoms and outcomes in certain forms of heart failure.
How does Irbesartan work?+
Irbesartan works by selectively antagonising the angiotensin II type 1 (AT1) receptor. By blocking this receptor, it prevents angiotensin II‑mediated vasoconstriction, aldosterone release, and sympathetic activation, resulting in vasodilation, reduced sodium and water retention, and lower systemic blood pressure.
What is the usual dose of Irbesartan Crescent Pharma?+
The appropriate dose of Irbesartan Crescent Pharma is determined by the prescribing clinician based on the patient’s medical condition, response to therapy, and renal function. Dosage adjustments are made individually; patients should follow the prescriber’s instructions and not alter the dose on their own.
Is Irbesartan safe during pregnancy or breastfeeding?+
Irbesartan is generally contraindicated during the second and third trimesters of pregnancy because it may harm the developing fetus. Safety during breastfeeding has not been established, so clinicians usually advise against use while nursing unless the benefits outweigh potential risks.
How do I order Irbesartan Crescent Pharma from GNH USA?+
To order Irbesartan Crescent Pharma, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and the necessary import documentation.
How does Irbesartan compare with other antihypertensive classes such as ACE inhibitors?+
Irbesartan belongs to the ARB class, which blocks the AT1 receptor downstream of the ACE step. Compared with ACE inhibitors, ARBs like Irbesartan are less likely to cause cough or angio‑edema, but both classes provide similar blood‑pressure‑lowering effects. Choice between them depends on patient tolerance, comorbidities, and physician preference.
How should Irbesartan Crescent Pharma be stored and handled?+
Irbesartan Crescent Pharma should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and excessive heat. Do not store in a refrigerator or freezer, and ensure the container is tightly closed when not in use.
How is Irbesartan Crescent Pharma administered?+
Irbesartan Crescent Pharma is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water. Patients should follow the dosing schedule prescribed by their healthcare provider and not crush or split the tablet unless specifically instructed.
What are the most serious risks to watch for while taking Irbesartan Crescent Pharma?+
Serious risks include hyperkalemia (elevated potassium levels), acute kidney injury, and angio‑edema, which can be life‑threatening. Patients should be alert for symptoms such as swelling of the face or throat, rapid weight gain, decreased urine output, or muscle weakness, and seek medical attention promptly if they occur.
Who should not use Irbesartan Crescent Pharma?+
Irbesartan Crescent Pharma should be avoided in patients with known hypersensitivity to irbesartan or any component of the formulation, in those with severe hepatic impairment, and in pregnant women during the second and third trimesters. Caution is also advised for individuals with severe renal dysfunction or uncontrolled hyperkalemia.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Irbesartan
Route
Oral Use
Manufacturer
Crescent Pharma Limited
Origin
EU

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