Irbesartan Comp Hexal

Irbesartan and Hydrochlorothiazide, the active ingredients in Irbesartan Comp Hexal, are an angiotensin II receptor blocker and a thiazide diuretic presented as tablets for oral use. They treat hypertension in adult patients by lowering blood pressure and reducing fluid retention. GNH USA supplies Irbesartan Comp Hexal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Irbesartan Comp Hexal acts on the renin‑angiotensin‑aldosterone system and renal sodium handling to control high blood pressure. - Hypertension: lowers systolic and diastolic pressure in adults. - Essential hypertension uncontrolled by monotherapy: provides additional blood‑pressure reduction when a single agent is insufficient. - Hypertension with fluid retention: combines antihypertensive and diuretic effects to improve overall control.

Common Side Effects: - Dizziness: sensation of light‑headedness, especially after standing. - Headache: mild to moderate pain in the head region. - Fatigue: feeling unusually tired or weak. - Increased urination: more frequent need to void. - Electrolyte imbalance: changes in potassium or sodium levels. - Mild gastrointestinal discomfort: nausea or abdominal pain.

Serious or Rare Side Effects: - Severe hypotension: dangerously low blood pressure. - Hyperkalemia: elevated potassium that can affect heart rhythm. - Acute kidney injury: sudden decline in renal function. - Allergic reactions: rash, itching, or swelling. - Pancreatitis: inflammation of the pancreas. - Blood dyscrasias: abnormal blood cell counts.

Before initiating therapy, consider the following precautions. - Blood pressure monitoring: check regularly to ensure adequate control. - Electrolyte assessment: evaluate potassium and sodium levels, especially with diuretic use. - Renal function: assess kidney function before and during treatment. - Hepatic impairment: use with caution in patients with liver disease. - Pregnancy and lactation: safety not established; avoid unless clearly needed. - Store below 25°C: keep in the original pack, protect from moisture.

Irbesartan Comp Hexal may interact with several medicines; review patient medication lists. Major Interactions (Avoid): - Aliskiren in diabetic patients: risk of severe hypotension and renal impairment. - Potassium‑sparing diuretics or supplements: may cause dangerous hyperkalemia. - NSAIDs (e.g., ibuprofen, naproxen): can blunt antihypertensive effect and affect kidney function. Moderate Interactions (Monitor Closely): - ACE inhibitors: additive blood‑pressure lowering, monitor for hypotension. - Lithium: increased lithium levels, watch for toxicity. - Other antihypertensives: may require dose adjustments. - Antidiabetic agents: blood‑glucose may improve, monitor for hypoglycemia. - CYP3A4 inhibitors: may increase irbesartan exposure, observe for adverse effects.