Irbesartan Arrow

Irbesartan, the active ingredient in Irbesartan Arrow, is a Angiotensin II receptor blocker (ARB) presented as an oral tablet for oral use. It treats hypertension and diabetic nephropathy in adult patients.

GNH USA supplies Irbesartan Arrow as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Irbesartan acts on the renin‑angiotensin system to lower blood pressure and protect kidney function. - Hypertension: reduces elevated arterial pressure and lowers cardiovascular risk. - Diabetic nephropathy: slows progression of kidney damage in patients with type 2 diabetes. - Chronic kidney disease associated with diabetes: helps preserve renal function by reducing intraglomerular pressure.

Common Side Effects: - Dizziness: sensation of light‑headedness, especially after standing. - Headache: mild to moderate pain in the head region. - Fatigue: feeling unusually tired or weak. - Upper respiratory infection: nasopharyngitis or mild cough. - Nausea: upset stomach, sometimes with vomiting. - Diarrhea: loose stools occurring intermittently.

Serious or Rare Side Effects: - Angioedema: rapid swelling of face, lips, tongue, or throat requiring emergency care. - Hyperkalemia: elevated blood potassium that may cause cardiac rhythm changes. - Acute renal impairment: sudden decline in kidney function, indicated by rising creatinine. - Hepatic injury: abnormal liver enzymes or jaundice. - Myocardial infarction: rare occurrence of heart attack, especially in patients with existing coronary disease.

Irbesartan should be used with clinical monitoring and patient education. - Blood pressure monitoring: check regularly to avoid hypotension. - Renal function assessment: evaluate serum creatinine and eGFR before and during therapy. - Serum potassium measurement: monitor for hyperkalemia, especially with concomitant potassium‑sparing agents. - Hepatic impairment: use caution and consider dose adjustment in patients with liver disease. - Pregnancy: avoid use; potential fetal toxicity is unknown. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Irbesartan may interact with several medicines, requiring attention to dosage and monitoring. Major Interactions (Avoid): - Aliskiren (in diabetic patients): combined use can increase renal risk. - Potassium‑sparing diuretics (e.g., spironolactone): may cause dangerous hyperkalemia. - ACE inhibitors (e.g., enalapril): concurrent use raises risk of angioedema and renal dysfunction. - Lithium: can increase lithium serum levels, leading to toxicity. - NSAIDs (high‑dose): may impair renal function and blunt antihypertensive effect. Moderate Interactions (Monitor Closely): - Thiazide diuretics: may enhance hypotensive effect; monitor blood pressure. - NSAIDs (low‑dose): watch renal parameters and electrolytes. - CYP2C9 inhibitors (e.g., fluconazole): may increase irbesartan plasma concentrations; adjust if needed.