Irbesartan And Hydrochlorothiazide Crescent Pharma

Irbesartan/Hydrochlorothiazide, the active ingredients in Irbesartan And Hydrochlorothiazide Crescent Pharma, are an Angiotensin II receptor blocker and a thiazide diuretic presented as oral tablets for systemic use. They are indicated for the treatment of hypertension in adult patients.

GNH USA supplies Irbesartan And Hydrochlorothiazide Crescent Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Irbesartan/Hydrochlorothiazide acts on the renin‑angiotensin‑aldosterone system and renal sodium handling to control elevated blood pressure. - Hypertension: lowers systolic and diastolic pressure in patients with primary hypertension. - Left ventricular hypertrophy: helps reduce cardiac workload associated with chronic high blood pressure. - Renal protection in hypertension: slows progression of hypertensive kidney disease by reducing intraglomerular pressure.

Common Side Effects: - Dizziness or light‑headedness - Headache - Fatigue or weakness - Increased urination - Electrolyte disturbances (e.g., low potassium) - Mild gastrointestinal upset

Serious or Rare Side Effects: - Severe dehydration or electrolyte imbalance - Hyperkalemia or severe hypokalemia - Acute kidney injury or worsening renal function - Angioedema or severe facial swelling - Hypotensive crisis - Anaphylactic reactions

Before initiating therapy, consider the following precautions: - Renal function: monitor serum creatinine and eGFR regularly. - Electrolytes: check potassium and sodium levels, especially when combined with other diuretics. - Pregnancy: avoid use unless clearly necessary, as safety is not established. - Elderly patients: start at the lowest effective dose and titrate cautiously. - Concomitant medications: review for potential interactions that may affect blood pressure or electrolyte balance. - Store at ambient temperature: keep tablets in the original container, protect from moisture and direct sunlight.

Irbesartan/Hydrochlorothiazide may interact with several medicines. Major Interactions (Avoid): - Potassium‑sparing diuretics or supplements: risk of hyperkalemia. - ACE inhibitors or aliskiren (in diabetes): additive renal effects. - Lithium: increased lithium levels and toxicity. - NSAIDs: may blunt antihypertensive effect and impair renal function. - Strong CYP2C9 inhibitors: may raise irbesartan concentrations.

Moderate Interactions (Monitor Closely): - Beta‑blockers: additive blood‑pressure lowering effect. - Calcium channel blockers: may enhance hypotensive response. - Antidiabetic agents: diuretic‑induced changes in glucose may require dose adjustment.