Invirum

Aciclovir, the active ingredient in Invirum, is an antiviral presented as an oral formulation for oral use. It treats herpes simplex virus infections, herpes zoster (shingles) and varicella (chickenpox) in patients requiring antiviral therapy, helping to reduce symptom severity and accelerate healing.

GNH USA supplies Invirum as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Aciclovir is used to manage infections caused by herpesviruses.

Herpes simplex virus infections: reduces lesion duration and severity in oral and genital outbreaks. Herpes zoster (shingles): alleviates pain and accelerates lesion healing in adults. Varicella (chickenpox): shortens disease course in children and adults.

Aciclovir may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Nausea - Headache - Diarrhea - Fatigue - Dizziness - Abdominal discomfort

Serious or Rare Side Effects: - Acute renal impairment - Severe allergic reactions (e.g., anaphylaxis) - Stevens‑Johnson syndrome or toxic epidermal necrolysis - Bone marrow suppression - Seizures - Hepatitis

Before initiating therapy, certain precautions should be considered.

Renal function: adjust dose in patients with impaired renal function. Hydration: maintain adequate fluid intake during treatment. Pregnancy: use only if the potential benefit justifies the potential risk to the fetus. Concurrent nephrotoxic drugs: monitor kidney function closely. Allergy: discontinue if signs of hypersensitivity appear. Store at ambient temperature: keep in the original container, protect from moisture and heat.

Aciclovir can interact with other medicines, affecting its safety or effectiveness.

Major Interactions (Avoid): - Probenecid: increases aciclovir plasma concentrations, raising toxicity risk. - Cimetidine: reduces renal clearance, potentially leading to accumulation. - Nephrotoxic agents (e.g., aminoglycosides): heighten risk of renal damage.

Moderate Interactions (Monitor Closely): - Warfarin: may alter INR; monitor coagulation parameters. - Immunosuppressants (e.g., cyclosporine): increased infection susceptibility; observe clinical response. - Oral contraceptives: may reduce efficacy; advise additional contraceptive measures.