Invicorp

Phentolamine mesilate and aviptadil, the active ingredient in Invicorp, is an alpha‑adrenergic antagonist and vasoactive intestinal peptide analog presented as an intracavernous injection for the treatment of erectile dysfunction in adult males. The combination works by blocking alpha‑adrenergic receptors to induce vasodilation and by stimulating smooth‑muscle relaxation through cAMP elevation, together enhancing penile blood flow.

GNH USA supplies Invicorp as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across markets.

Invicorp acts on the penile vascular system to restore normal erectile function. - Erectile dysfunction: improves erection quality by increasing blood flow to the corpus cavernosum. - Penile vascular insufficiency: enhances arterial inflow to support adequate rigidity. - Post‑operative penile rehabilitation: aids recovery of erectile function after surgical procedures.

Adverse reactions may occur following intracavernous administration.

Common Side Effects: - Injection site pain: mild to moderate discomfort at the injection site. - Bruising or hematoma: localized bleeding under the skin. - Swelling: transient edema of the penis. - Erythema: redness around the injection area. - Headache: occasional mild headache. - Dizziness: transient light‑headedness.

Serious or Rare Side Effects: - Priapism: prolonged erection lasting more than four hours. - Severe hypotension: sudden drop in blood pressure requiring medical attention. - Allergic reaction: rash, itching, or anaphylaxis. - Cardiovascular collapse: rare but life‑threatening drop in circulatory function. - Infection at injection site: signs of redness, warmth, or purulent discharge. - Prolonged erection with tissue damage: risk of penile fibrosis if untreated.

Before using Invicorp, consider the following safety measures. - Contraindicated in severe cardiovascular disease: risk of dangerous hypotension. - Avoid in patients with known hypersensitivity to phentolamine or aviptadil: may trigger allergic reactions. - Use caution in sickle cell disease: increased risk of priapism. - Monitor blood pressure before and after injection: watch for sudden drops. - Review concomitant vasodilator therapy: adjust dosing as needed. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Invicorp may interact with several medication classes.

Major Interactions (Avoid): - Nitrates: additive vasodilation can cause severe hypotension. - Alpha‑blockers: combined effect may lead to profound blood pressure fall. - PDE5 inhibitors: heightened risk of priapism.

Moderate Interactions (Monitor Closely): - Antihypertensives: may require dose adjustment and close blood pressure monitoring. - Beta‑blockers: monitor heart rate and hemodynamic response. - Diuretics: watch for electrolyte disturbances and volume depletion.