Intrafusin

Valine, Acetylcysteine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, the active ingredient in Intrafusin, is a nutrition supplement presented as a solution for injection for intravenous use. It provides essential and non‑essential amino acids to support protein synthesis and metabolic processes in patients requiring parenteral nutrition.

GNH USA supplies Intrafusin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, pharmacies and clinics worldwide.

Intrafusin is used in parenteral nutrition to supply amino acids for patients unable to receive oral intake.

Severe malnutrition: supports protein synthesis and nitrogen balance. Post‑operative recovery: provides essential amino acids for tissue repair. Critical illness (e.g., sepsis, trauma): maintains metabolic needs when enteral feeding is contraindicated.

Intrafusin may be associated with infusion‑related and metabolic reactions.

Common Side Effects: - Infusion site erythema: mild redness at the catheter site. - Mild nausea: transient discomfort during or after infusion. - Transient hyperglycemia: temporary rise in blood glucose levels. - Electrolyte shift (e.g., mild hypokalemia): small changes in serum potassium.

Serious or Rare Side Effects: - Anaphylactic reaction: severe allergic response requiring immediate medical attention. - Severe hyperosmolarity: marked increase in plasma osmolality. - Metabolic acidosis: significant drop in blood pH. - Thrombophlebitis: inflammation of a vein with clot formation.

When using Intrafusin, clinicians should consider several safety aspects.

Renal impairment: monitor serum creatinine and adjust infusion rate. Liver dysfunction: assess amino acid metabolism and liver function tests. Electrolyte disorders: check serum electrolytes before and during therapy. Hyperglycemia risk: monitor blood glucose in diabetic patients. Allergy to any component: discontinue if hypersensitivity occurs. Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Intrafusin can interact with other intravenous agents and systemic therapies.

Major Interactions (Avoid): - Concurrent high‑dose potassium supplements: may cause hyperkalemia. - Incompatible IV solutions (e.g., calcium chloride): can precipitate.

Moderate Interactions (Monitor Closely): - Insulin therapy: may require dose adjustment due to glucose load. - Diuretics: monitor electrolyte balance. - Other parenteral nutrition admixtures: assess total amino acid and nitrogen load.