Intiflor

Fluconazole, the active ingredient in Intiflor, is a triazole antifungal presented as an oral tablet for oral use. It treats a range of fungal infections and is prescribed for both adult and pediatric patients as appropriate. GNH USA supplies Intiflor as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Fluconazole is a triazole antifungal that acts on yeast and mold infections. - Vulvovaginal candidiasis: relieves symptoms and eradicates the yeast infection. - Oropharyngeal candidiasis: clears yeast overgrowth in the mouth and throat. - Systemic candidiasis: treats invasive Candida infections in the bloodstream and organs. - Cryptococcal meningitis (maintenance therapy): prevents recurrence of fungal meningitis after initial treatment.

Fluconazole may cause a variety of adverse reactions, ranging from mild to severe.

Common Side Effects: - Nausea - Headache - Abdominal pain or discomfort - Diarrhea - Rash or mild skin irritation - Altered taste sensation

Serious or Rare Side Effects: - Severe liver injury or hepatitis - Stevens‑Johnson syndrome and toxic epidermal necrolysis - Anaphylactic or severe allergic reactions - Blood dyscrasias such as neutropenia or thrombocytopenia - QT interval prolongation leading to cardiac arrhythmias - Severe skin reactions including drug rash with eosinophilia and systemic symptoms (DRESS).

Before initiating fluconazole therapy, consider the following safety measures. - Renal impairment: assess kidney function and adjust dose if necessary. - Hepatic impairment: monitor liver enzymes regularly during treatment. - Drug interactions: review all concomitant medications for potential interactions. - Pregnancy: use only if the potential benefit justifies the potential risk to the fetus. - Elderly patients: observe for increased susceptibility to toxicity and adverse effects. - Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

Fluconazole can interact with several medicines, requiring careful management.

Major Interactions (Avoid): - Ritonavir and other protease inhibitors: may markedly increase fluconazole plasma levels. - Terbinafine: combined use raises the risk of hepatotoxicity. - Cisapride: co‑administration can lead to dangerous QT prolongation. - Other azole antifungals (e.g., ketoconazole): may cause additive toxicity.

Moderate Interactions (Monitor Closely): - Warfarin: fluconazole can enhance anticoagulant effect, increasing INR. - Phenytoin: may reduce fluconazole concentrations, diminishing efficacy. - Oral hypoglycemic agents: risk of enhanced hypoglycemia. - Statins (especially simvastatin): increased risk of myopathy and rhabdomyolysis.