Intestil

Pinaverium bromide, the active ingredient in Intestil, is a calcium channel blocker (antispasmodic) presented as an oral dosage form for oral use. It treats abdominal pain caused by intestinal spasm in adults with irritable bowel syndrome and other functional bowel disorders.

GNH USA supplies Intestil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Intestil (pinaverium bromide) is used to manage functional gastrointestinal disorders by relaxing smooth muscle tone.

- Irritable bowel syndrome: reduces abdominal pain and cramping associated with IBS. - Functional bowel disorders: alleviates discomfort and improves bowel habit in chronic functional conditions. - Abdominal pain due to intestinal spasm: provides symptomatic relief of spasm‑related pain.

Adverse reactions may occur with any antispasmodic therapy.

Common Side Effects: - Dry mouth: mild reduction in salivary flow. - Nausea: transient stomach upset. - Headache: mild tension‑type headache. - Dizziness: occasional light‑headedness. - Constipation: reduced bowel motility. - Fatigue: low‑grade tiredness.

Serious or Rare Side Effects: - Severe allergic reaction: rash, swelling, or anaphylaxis. - Cardiac arrhythmia: abnormal heart rhythm in susceptible patients. - Hepatotoxicity: elevated liver enzymes. - Severe hypotension: marked drop in blood pressure. - Muscle weakness: generalized weakness beyond expected relief. - Persistent diarrhea: severe watery stools.

Before initiating therapy, consider the following precautions.

- Pregnancy: safety not established; use only if benefit outweighs risk. - Breastfeeding: unknown excretion; weigh potential infant exposure. - Renal impairment: monitor for accumulation in severe dysfunction. - Hepatic disease: use cautiously; liver function may affect metabolism. - Concomitant anticholinergics: may enhance antispasmodic effect and increase dry‑mouth risk. - Store at ambient temperature: keep below 25°C in the original container, protect from moisture and direct sunlight.

Pinaverium bromide may interact with other medicines.

Major Interactions (Avoid): - Other calcium channel blockers: additive smooth‑muscle relaxation may cause hypotension. - Strong CYP3A4 inhibitors: potential increase in systemic exposure. - Potassium‑sparing diuretics: risk of hyperkalemia when combined.

Moderate Interactions (Monitor Closely): - Anticholinergic agents: may exacerbate dry‑mouth and constipation. - Tricyclic antidepressants: possible enhancement of GI motility changes. - Macrolide antibiotics: may alter intestinal absorption of pinaverium.