Instillagel

Chlorhexidine Gluconate, the active ingredient in Instillagel, is an antiseptic presented as a gel for rectal, urethral and vaginal use. It provides antimicrobial protection and local analgesia to mucosal surfaces. Instillagel also contains lidocaine hydrochloride for additional local anesthesia.

GNH USA supplies Instillagel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Instillagel, a chlorhexidine‑based antiseptic and lidocaine local‑anesthetic gel, is applied to mucosal surfaces of the lower genitourinary tract.

- Rectal mucosal antisepsis: cleanses and reduces bacterial load before procedures such as proctoscopy. - Urethral preparation: lowers microbial count prior to catheterisation or endoscopic interventions. - Vaginal antiseptic and analgesia: provides cleansing and numbing before gynecological examinations or surgeries.

Instillagel may cause local reactions when applied to mucosal surfaces.

Common Side Effects: - Burning or stinging sensation at the application site. - Mild itching or irritation of the mucosa. - Transient numbness that resolves after a short period. - Local redness or mild erythema. - Allergic contact dermatitis in sensitised individuals. - Slight discomfort during application.

Serious or Rare Side Effects: - Anaphylactic reaction with systemic symptoms. - Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Severe mucosal ulceration or necrosis. - Systemic toxicity from lidocaine absorption (rare). - Persistent numbness beyond expected duration. - Severe hypersensitivity requiring medical intervention.

Before using Instillagel, consider the following safety measures.

- Allergy assessment: avoid if known hypersensitivity to chlorhexidine, lidocaine, or parabens. - Pregnancy: use only if clearly needed; safety data are limited. - Breastfeeding: consider potential exposure to the infant; consult a clinician. - Mucosal integrity: do not apply to severely damaged or ulcerated tissue. - Ophthalmic exposure: avoid contact with eyes; if accidental, rinse thoroughly. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Instillagel may interact with other medicines when used concurrently.

Major Interactions (Avoid): - Other local anesthetics: concurrent use may increase systemic lidocaine levels. - Alcohol‑based antiseptics: combined use can cause increased irritation. - Systemic chlorhexidine preparations: may lead to additive toxicity.

Moderate Interactions (Monitor Closely): - Anticholinergic drugs: may potentiate local anesthetic effects. - Beta‑blockers: could affect lidocaine metabolism and clearance. - Renal impairment: monitor for accumulation of lidocaine.