Instillagel

Chlorhexidine Gluconate and Lidocaine Hydrochloride, the active ingredient in Instillagel, is an antiseptic and local anesthetic presented as a gel for urethral use. It helps prevent bacterial infection and provides analgesia during urethral catheterisation and related procedures.

GNH USA supplies Instillagel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and clinics worldwide.

Instillagel combines an antiseptic and a local anaesthetic to protect the urethra and reduce discomfort during catheter‑related procedures. - Prevention of infection during urethral catheterisation: reduces bacterial colonisation of the urethral mucosa. - Local analgesia of the urethra: provides pain relief while the catheter is inserted or removed. - Urethral antisepsis prior to diagnostic or therapeutic procedures: maintains sterility of the urinary tract.

Instillagel may cause local and systemic reactions, most of which are mild and transient.

Common Side Effects: - Burning or stinging sensation at the application site. - Mild urethral irritation or discomfort. - Transient dysuria (painful urination). - Localised redness or erythema. - Headache. - Nausea.

Serious or Rare Side Effects: - Anaphylactic reaction or severe hypersensitivity. - Significant urethral ulceration or necrosis. - Systemic toxicity from lidocaine (e.g., CNS symptoms, cardiac arrhythmia). - Persistent severe pain or swelling. - Severe allergic dermatitis. - Acute renal impairment secondary to systemic absorption (very rare).

Before using Instillagel, consider the following safety measures. - Allergy assessment: avoid if the patient has known hypersensitivity to chlorhexidine or lidocaine. - Pregnancy: use only if the anticipated benefit justifies potential risk to the fetus. - Breastfeeding: limited data; evaluate risk versus benefit. - Urethral trauma: do not apply to severely injured or inflamed urethral tissue. - Concomitant topical anesthetics: monitor for additive local‑anaesthetic effects. - Store at room temperature: keep in the original container, protect from moisture and direct heat.

Instillagel may interact with other agents; awareness helps minimise risk.

Major Interactions (Avoid): - Concurrent use of other chlorhexidine‑containing products: may increase local irritation. - Systemic local anaesthetics (e.g., bupivacaine, ropivacaine): risk of additive lidocaine toxicity.

Moderate Interactions (Monitor Closely): - Anticoagulants (e.g., warfarin): monitor for bleeding if urethral trauma occurs. - Antihistamines: may mask early signs of allergic reaction. - Certain antibiotics (e.g., aminoglycosides): watch for enhanced nephrotoxicity if systemic absorption occurs.