Instillagel

Chlorhexidine gluconate and lidocaine hydrochloride, the active ingredients in Instillagel, are an antiseptic and a local anesthetic presented as a gel for urethral use. They provide antimicrobial protection and pain relief during catheterisation and other urethral procedures in adult patients.

GNH USA supplies Instillagel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide. With a focus on safety and efficacy, the company supports clinical teams with timely product availability, technical support, and reliable distribution across multiple regions.

Instillagel is used in the urinary tract to provide antiseptic protection and local analgesia during invasive procedures.

Urinary catheterisation: reduces the risk of infection by delivering broad‑spectrum antimicrobial activity. Urethral instrumentation: provides rapid local anesthesia to minimise patient discomfort. Urethral surgery: offers both infection prophylaxis and analgesia during operative manipulation.

Instillagel may cause local reactions at the application site.

Common Side Effects: - Burning or stinging sensation during or after application. - Mild urethral irritation or redness. - Transient dysuria (painful urination). - Local swelling or edema. - Minor allergic skin reaction (rash or itching). - Temporary alteration of urine colour.

Serious or Rare Side Effects: - Anaphylactic reaction (difficulty breathing, swelling of face or throat). - Severe chemical urethritis with intense pain. - Systemic lidocaine toxicity (dizziness, tinnitus, seizures) if absorbed in large amounts. - Significant tissue necrosis at the application site. - Persistent urinary retention requiring medical intervention. - Unexplained fever or systemic infection after use.

Before using Instillagel, consider the following safety measures.

Allergy assessment: avoid if the patient has known hypersensitivity to chlorhexidine or lidocaine. Pregnancy: use only when the benefit outweighs potential risk; data are limited. Breastfeeding: exercise caution as minimal systemic absorption may occur. Urethral injury: do not apply to damaged or ulcerated mucosa. Concurrent antiseptics: avoid mixing with other chlorhexidine‑containing products to reduce irritation risk. Store at below 25°C: keep in the original container, protect from moisture and heat.

Instillagel can interact with certain medications; monitor as indicated.

Major Interactions (Avoid): - Systemic local anesthetics: additive toxicity may increase risk of lidocaine‑related adverse effects. - Other chlorhexidine‑containing products: may cause excessive local irritation. - Prolonged catheter use with Instillagel: could promote bacterial resistance.

Moderate Interactions (Monitor Closely): - Anticoagulants: heightened bleeding risk if mucosal injury occurs. - Beta‑blockers: may enhance systemic lidocaine effects. - Renal impairment: monitor for increased systemic absorption and toxicity.