Instillagel

Chlorhexidine Gluconate and Lidocaine Hydrochloride, the active ingredient in Instillagel, is an antiseptic and local anesthetic presented as a gel for urethral use. It provides antimicrobial protection and pain relief during urethral procedures and helps prevent urinary tract infections in catheterised patients.

GNH USA supplies Instillagel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide across multiple regions and regulatory environments, with a focus on quality assurance and timely delivery, and comprehensive support.

Instillagel, containing chlorhexidine and lidocaine, is used in the urological antiseptic pathway to manage infection risk and provide local anesthesia.

- Urethral antisepsis: reduces microbial load in the urethra before instrumentation, decreasing infection risk. - Catheterisation prophylaxis: helps prevent urinary tract infections during catheter placement by providing sustained antiseptic activity. - Local anaesthesia for urethral procedures: provides rapid pain relief during cystoscopy, catheter insertion, or other urethral interventions, improving patient comfort.

Instillagel may cause local adverse reactions at the application site.

Common Side Effects: - Burning sensation: mild transient burning in the urethra. - Stinging: brief stinging upon instillation. - Redness: localized erythema of urethral mucosa. - Discomfort: mild discomfort during or after application.

Serious or Rare Side Effects: - Allergic reaction: rash, urticaria, or angioedema. - Severe urethral irritation: persistent pain or ulceration. - Systemic toxicity: signs of lidocaine overdose such as dizziness, tremor, or seizures (rare).

Before using Instillagel, certain precautions should be observed to ensure safety and effectiveness.

- Assess allergy: confirm no known hypersensitivity to chlorhexidine or lidocaine. - Use in compromised mucosa: avoid if urethral trauma or severe inflammation is present. - Pregnancy and lactation: use only if benefit outweighs risk; consult a physician. - Drug interactions: avoid concurrent use of other local anesthetics to prevent additive toxicity. - Monitor for systemic signs: observe for signs of lidocaine toxicity, especially with prolonged exposure. - Store at ambient temperature: keep in original container, protect from light and moisture.

Instillagel can interact with other medicines or substances; awareness of these interactions helps prevent adverse effects.

Major Interactions (Avoid): - Other local anesthetics: concurrent use may increase risk of systemic toxicity. - Systemic lidocaine: avoid simultaneous intravenous lidocaine administration. - Chlorhexidine-containing products: using multiple chlorhexidine preparations may cause irritation.

Moderate Interactions (Monitor Closely): - Anticholinergic drugs: may affect bladder function; monitor urinary symptoms. - Beta‑blockers: may potentiate lidocaine cardiac effects; observe heart rate. - CYP450 inhibitors: may slow lidocaine metabolism; watch for increased plasma levels.