Inspra

Eplerenone, the active ingredient in Inspra, is an aldosterone antagonist presented as a unknown/unknown for oral use. It treats hypertension and heart failure in adults. GNH USA supplies Inspra as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Inspra, an aldosterone antagonist, is used in cardiovascular conditions where mineralocorticoid blockade is beneficial. Hypertension: lowers blood pressure by reducing sodium retention. Heart failure: improves cardiac function and reduces hospitalization risk. Post‑myocardial infarction: decreases the chance of cardiovascular death and recurrent heart‑failure events.

Common Side Effects: - Dizziness or light‑headedness - Headache - Fatigue or weakness - Nausea or abdominal discomfort - Diarrhea or constipation - Elevated blood urea nitrogen (BUN)

Serious or Rare Side Effects: - Hyperkalemia (high potassium levels) - Acute kidney injury or worsening renal function - Severe allergic reactions, including rash or angioedema - Hepatic dysfunction or jaundice - Gynecomastia (rare breast tissue enlargement) - Life‑threatening arrhythmias in the setting of marked hyperkalemia

Before initiating therapy, consider the following precautions: - Monitor serum potassium: check baseline and periodic levels. - Assess renal function: evaluate creatinine and eGFR before and during treatment. - Use caution in patients with diabetes mellitus due to altered electrolyte handling. - Avoid in severe hepatic impairment unless benefits outweigh risks. - Review concomitant medications that may raise potassium or affect renal clearance. - Store at below 25°C: keep in the original pack, protect from moisture.

Eplerenone may interact with several drug classes; awareness helps prevent adverse events. Major Interactions (Avoid): - ACE inhibitors or ARBs: combined use can cause significant hyperkalemia. - Potassium‑sparing diuretics (e.g., spironolactone, amiloride): increase risk of elevated potassium. - Potassium supplements or salt substitutes containing potassium. - Cyclosporine or tacrolimus: may raise eplerenone levels.

Moderate Interactions (Monitor Closely): - NSAIDs: can impair renal function and raise potassium. - Thiazide diuretics: may affect electrolyte balance. - Digoxin: monitor for signs of toxicity when potassium is high. - Lithium: altered renal clearance may increase lithium levels.