GNH USA

Europe — EMA

Inspiolto Respimat

GNH USA supplies Inspiolto Respimat (Tiotropium, Olodaterol), a long‑acting muscarinic antagonist / long‑acting β2‑agonist bronchodilator for COPD

Tiotropium, Olodaterol

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What is Tiotropium, Olodaterol?

Tiotropium and Olodaterol, the active ingredients in Inspiolto Respimat, are a long‑acting muscarinic antagonist / long‑acting β2‑agonist combination presented as a Respimat soft‑mist inhaler for inhalation use. It provides maintenance bronchodilator therapy for adults with chronic obstructive pulmonary disease (COPD).

GNH USA supplies Inspiolto Respimat as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Tiotropium, Olodaterol used for?

Inspiolto Respimat is indicated for chronic obstructive pulmonary disease (COPD) as a maintenance bronchodilator therapy.

- Chronic obstructive pulmonary disease (COPD): Improves lung function and reduces dyspnea, supporting daily activities. - COPD exacerbations: Lowers the frequency of moderate to severe exacerbations when used regularly. - Bronchospasm in COPD: Provides sustained bronchodilation to relieve airway narrowing.

What are the side effects of Tiotropium, Olodaterol?

Common Side Effects: - Dry mouth: Reduced salivary secretion may cause a sensation of dryness. - Cough: Transient irritation of the airway during inhalation. - Throat irritation: Mild discomfort in the throat after use. - Headache: Occasional mild headache reported.

Serious or Rare Side Effects: - Paradoxical bronchospasm: Sudden worsening of breathing difficulty. - Angioedema: Swelling of face, lips, tongue, or throat requiring urgent care. - Severe allergic reaction: Rash, itching, or anaphylaxis. - Tachycardia or arrhythmia: Increased heart rate or irregular rhythm.

What precautions apply to Tiotropium, Olodaterol?

Before prescribing Inspiolto Respimat, clinicians should consider the following precautions.

- Assess renal function: Tiotropium is renally excreted; use with caution in severe impairment. - Monitor cardiovascular status: Olodaterol may increase heart rate; avoid in uncontrolled arrhythmias. - Avoid use in acute bronchospasm: Not intended for rescue therapy. - Ensure proper inhaler technique: Correct priming and inhalation are essential for efficacy. - Store at room temperature: Keep inhaler in original packaging, protect from moisture and heat.

What does Tiotropium, Olodaterol interact with?

Inspiolto Respimat may interact with other medicines; review patient medication lists.

Major Interactions (Avoid): - Concurrent anticholinergics: May increase anticholinergic side effects. - Beta‑blockers: Can diminish the bronchodilator effect of olodaterol. - Strong CYP2C8 inhibitors: May raise olodaterol plasma concentrations.

Moderate Interactions (Monitor Closely): - Diuretics: May exacerbate dry mouth. - Antihistamines: Potential additive anticholinergic burden.

Frequently asked questions

What is Inspiolto Respimat used for?+
Inspiolto Respimat is a prescription inhaler that combines tiotropium and olodaterol to provide long‑acting bronchodilation for maintenance therapy in adults with chronic obstructive pulmonary disease (COPD). It helps improve lung function, reduce symptoms such as breathlessness, and lower the risk of COPD exacerbations when used regularly as part of a comprehensive treatment plan.
How does tiotropium and olodaterol work in the lungs?+
Tiotropium blocks muscarinic M3 receptors on airway smooth muscle, preventing acetylcholine‑induced constriction, while olodaterol activates β2‑adrenergic receptors, increasing cyclic AMP and causing smooth‑muscle relaxation. The dual mechanism produces sustained bronchodilation, keeping the airways open and improving airflow for patients with COPD.
What is the usual dose of Inspiolto Respimat?+
The prescribed dose of Inspiolto Respimat is determined by the treating physician based on the patient’s clinical condition, severity of COPD, and response to therapy. The inhaler delivers a fixed combination of tiotropium and olodaterol per actuation, and the prescriber will specify the number of inhalations and frequency appropriate for each individual.
Is Inspiolto Respimat safe during pregnancy or breastfeeding?+
Safety data for tiotropium and olodaterol in pregnancy and lactation are limited. The product should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss the risks and alternatives with their healthcare provider.
How do I order Inspiolto Respimat from GNH USA?+
To order Inspiolto Respimat, submit an enquiry on the product page at gnh-usa.com, indicating the required quantity. GNH USA supplies hospitals, pharmacies, and procurement teams across international markets. After the request, the sales team will verify trade or institutional credentials, then respond with pricing, availability, shipping details (including any cold‑chain requirements), and required import documentation.
How does Inspiolto Respimat compare with other COPD inhalers?+
Inspiolto Respimat combines a long‑acting muscarinic antagonist (LAMA) and a long‑acting β2‑agonist (LABA) in a single soft‑mist inhaler, offering dual bronchodilation. Compared with single‑component inhalers, it provides broader receptor coverage, potentially improving symptom control and reducing exacerbations. Its Respimat device creates a fine mist that may enhance lung deposition versus some dry‑powder inhalers, but choice of therapy should be individualized based on patient preference, technique, and clinical response.
What are the storage and handling requirements for Inspiolto Respimat?+
Store at room temperature: Keep the Respimat inhaler in its original packaging, protected from moisture, direct sunlight, and excessive heat. Do not expose the device to temperatures above 30 °C for prolonged periods. The inhaler does not require refrigeration, but it should be kept upright and the cartridge should be replaced according to the manufacturer’s schedule.
How is Inspiolto Respimat administered?+
Inspiolto Respimat is used by inhalation through a soft‑mist device. Before first use, the inhaler must be primed according to the instructions. The patient exhales fully, places the mouthpiece in the mouth, and inhales slowly and deeply while activating the device. After inhalation, the patient should hold their breath for about 10 seconds, then breathe out normally. The inhaler should be cleaned regularly as directed.
What are the most serious risks associated with Inspiolto Respimat?+
Serious risks include paradoxical bronchospasm, which can worsen breathing difficulty, and allergic reactions such as angioedema or anaphylaxis that require immediate medical attention. Cardiovascular effects like tachycardia, arrhythmias, or increased blood pressure may occur, especially in patients with pre‑existing heart conditions. Patients should be instructed to seek urgent care if they experience swelling of the face or throat, severe shortness of breath, or rapid heart rhythm.
Who should not use Inspiolto Respimat?+
Inspiolto Respimat should not be used in patients with known hypersensitivity to tiotropium, olodaterol, or any excipients of the inhaler. It is also contraindicated for acute bronchospasm or as a rescue medication. Caution is advised in individuals with severe renal impairment, uncontrolled cardiovascular disease, or those taking medications that may interact significantly, such as strong anticholinergics or beta‑blockers.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Tiotropium, Olodaterol
Route
Inhalation Use
Manufacturer
Boehringer Ingelheim International Gmbh
Origin
EU

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