Inprosub

Progesterone, the active ingredient in Inprosub, is a progestogen presented as a sterile injectable for intramuscular, subcutaneous use. It supports the menstrual cycle, endometrial development, and maintenance of early pregnancy, particularly in assisted reproductive treatments. GNH USA supplies Inprosub as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Progesterone in Inprosub acts on the hormonal pathways that regulate the menstrual cycle and early pregnancy. - Luteal phase support in assisted reproductive technology: maintains the uterine lining to improve implantation success. - Prevention of preterm birth in women with a history of recurrent miscarriage: helps sustain pregnancy until term. - Hormone replacement therapy in post‑menopausal women: alleviates symptoms associated with low progesterone levels.

Progesterone therapy can be associated with a range of adverse reactions.

Common Side Effects: - Injection site pain or irritation: mild discomfort at the administration site. - Headache: transient, often resolves without intervention. - Nausea or mild gastrointestinal upset. - Breast tenderness or swelling. - Mood changes: irritability or mild depression. - Fluid retention: mild edema.

Serious or Rare Side Effects: - Allergic reaction: rash, itching, or anaphylaxis. - Thromboembolic events: deep vein thrombosis or pulmonary embolism. - Severe hypertension: sudden increase in blood pressure. - Liver dysfunction: abnormal liver enzymes. - Hyperglycemia: elevated blood glucose levels. - Severe mood disturbances: suicidal ideation.

When prescribing Inprosub, clinicians should consider several safety measures. - Assess patient history: evaluate for clotting disorders, hypertension, or liver disease. - Monitor hormone levels: adjust therapy based on serum progesterone concentrations. - Review concomitant medications: avoid drugs that increase thrombosis risk. - Pregnancy and lactation: use only if benefits outweigh potential risks. - Patient counseling: inform about possible injection site reactions and systemic effects. Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Progesterone may interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of bleeding. - CYP3A4 inducers (e.g., rifampin): reduced progesterone plasma levels. - Hormonal contraceptives: potential additive hormonal effects.

Moderate Interactions (Monitor Closely): - Antidiabetic agents: possible hyperglycemia. - Antihypertensives: may affect blood pressure control. - Certain antibiotics (e.g., macrolides): modest impact on metabolism.