Inprosub

Progesterone, the active ingredient in Inprosub, is a Progestogen presented as a subcutaneous formulation for subcutaneous use. It is employed in hormone therapy to support progesterone levels in appropriate patient populations.

GNH USA supplies Inprosub as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Progesterone is a progestogen that acts on the reproductive hormone pathway and is employed in several therapeutic areas.

Luteal phase support in assisted reproductive technology: helps maintain the uterine lining for embryo implantation. Hormone replacement therapy in menopausal women: provides progesterone to counterbalance estrogen effects. Prevention of preterm birth in women with a short cervix: reduces the risk of early delivery.

Progesterone therapy may be associated with a range of adverse reactions.

Common Side Effects: - Injection site pain or erythema - Headache - Nausea or vomiting - Breast tenderness - Mood swings or irritability - Fluid retention

Serious or Rare Side Effects: - Allergic reaction or anaphylaxis - Thromboembolic events (deep vein thrombosis, pulmonary embolism) - Severe depression or mood disorders - Hepatic dysfunction - Severe hypertension - Adrenal insufficiency

Progesterone therapy requires careful patient assessment and monitoring.

Assess indication: confirm that progesterone supplementation is clinically appropriate. Monitor thromboembolic risk: evaluate history of clotting disorders before initiation. Observe for allergic reactions: discontinue if signs of hypersensitivity appear. Evaluate liver function: use with caution in patients with hepatic impairment. Review concomitant hormone therapy: adjust doses to avoid excess estrogen exposure. Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Progesterone can interact with several drug classes, necessitating vigilance.

Major Interactions (Avoid): - Combined estrogen‑progestogen therapy: increased risk of thromboembolic events. - CYP450 inducers (e.g., rifampin): may reduce progesterone plasma levels. - Antifungal azoles (e.g., ketoconazole): may increase progesterone concentrations.

Moderate Interactions (Monitor Closely): - Antidepressants (SSRIs): may alter mood-related side effects. - Antihypertensives: progesterone may affect blood pressure control. - Diuretics: potential impact on fluid balance and electrolyte status.