Inprosub

Progesterone, the active ingredient in Inprosub, is a progestogen presented as a subcutaneous formulation for injection use. It is employed in hormone therapy to support the endometrium, assist luteal phase support in assisted reproduction, and help reduce the risk of preterm birth in selected women.

GNH USA supplies Inprosub as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution. Customers benefit from comprehensive regulatory support and traceability throughout the supply chain.

Progesterone, as delivered by Inprosub, is used in several hormone‑related therapeutic pathways. - Hormone replacement therapy (HRT): provides progestogenic support to counterbalance estrogen and protect the endometrium in postmenopausal women. - Luteal phase support in assisted reproductive technology: maintains a receptive endometrial lining to improve implantation rates after embryo transfer. - Prevention of preterm birth in high‑risk pregnancies: reduces the incidence of early labor in women with a short cervix or prior preterm delivery.

Progesterone administered via Inprosub may be associated with a range of adverse reactions.

Common Side Effects: - Injection site pain - Redness or swelling at the injection site - Headache - Nausea - Breast tenderness

Serious or Rare Side Effects: - Thromboembolic events (deep vein thrombosis, pulmonary embolism) - Severe allergic reaction or anaphylaxis - Hyperglycemia or worsening diabetes control - Hepatic dysfunction or jaundice

When prescribing Inprosub, clinicians should consider several safety precautions. - Assess thromboembolic risk: evaluate history of clotting disorders before use. - Monitor blood pressure: progesterone can influence vascular tone. - Avoid in known hypersensitivity: discontinue if allergic reaction occurs. - Use caution in hepatic impairment: adjust therapy if liver function is compromised. - Consider pregnancy status: weigh benefits against potential fetal effects. - Store at ambient temperature: keep in original container, protect from moisture and light.

Progesterone can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of bleeding. - Hormonal contraceptives: may alter combined hormone levels. - CYP3A4 inducers (e.g., rifampin): reduce progesterone effectiveness. - CYP3A4 inhibitors (e.g., ketoconazole): raise progesterone concentrations. - Estrogen therapy: heightened risk of thromboembolic events.

Moderate Interactions (Monitor Closely): - Antidiabetic agents: progesterone may affect glucose control. - Corticosteroids: potential additive effect on adrenal axis. - Lithium: monitor serum lithium levels. - Phenobarbital: may diminish progesterone action. - SSRIs: possible mood alterations.