Inprosub

Progesterone, the active ingredient in Inprosub, is a progestogen presented as an injectable solution for intramuscular, subcutaneous use. It treats hormonal deficiencies, supports luteal phase in assisted reproduction, prevents preterm birth, and is used in hormone replacement therapy.

GNH USA supplies Inprosub as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Progesterone, a progestogen, is used in several reproductive and hormonal indications.

- Luteal phase support in assisted reproduction: enhances endometrial receptivity and improves implantation rates. - Prevention of preterm birth: reduces the risk of early delivery in high‑risk pregnancies. - Hormone replacement therapy: restores hormonal balance in menopausal or hypo‑estrogenic women. - Treatment of menstrual disorders: regulates the menstrual cycle and alleviates abnormal bleeding.

Progesterone injectable solution may be associated with several adverse reactions.

Common Side Effects: - Injection site pain: mild to moderate discomfort at the injection site. - Local swelling or erythema: transient redness or swelling. - Nausea: occasional feeling of queasiness. - Headache: mild headache episodes.

Serious or Rare Side Effects: - Thromboembolic events: rare clot formation. - Allergic reaction (including anaphylaxis): rash, itching, or severe hypersensitivity. - Hyperglycemia: elevated blood glucose levels. - Hepatic dysfunction: abnormal liver enzyme elevations.

When using Inprosub, consider the following precautions: - Patient assessment: evaluate history of thromboembolic disease before use. - Hormone‑sensitive conditions: avoid in active breast or endometrial cancer. - Diabetes monitoring: monitor blood glucose in diabetic patients. - Pregnancy status: confirm gestational age and risk factors prior to administration. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Progesterone may interact with several medications.

Major Interactions (Avoid): - Anticoagulants: may increase risk of bleeding. - CYP3A4 inducers: may reduce progesterone efficacy. - Hormonal contraceptives: additive progestogenic effects may cause hormonal imbalance.

Moderate Interactions (Monitor Closely): - Antidiabetic drugs: progesterone may affect glucose control. - Antihypertensives: possible fluid retention may alter blood pressure. - Antifungal azoles: may increase progesterone levels.