Infirem

Dapoxetine, the active ingredient in Infirem, is a selective serotonin reuptake inhibitor (SSRI) presented as an oral tablet for oral administration. It works by modulating serotonergic pathways to delay ejaculation, and is prescribed for the management of premature ejaculation in adult male patients seeking improved sexual control.

GNH USA supplies Infirem as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics worldwide in accordance with European Union quality standards.

Infirem (dapoxetine) is an SSRI used in the management of premature ejaculation.

Premature ejaculation: delays ejaculation to improve sexual satisfaction and control.

Infirem may cause a range of adverse reactions. Patients should be aware of both frequent and rare events.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Headache: tension‑type or throbbing pain. - Dizziness: sensation of light‑headedness. - Diarrhoea: loose stools. - Insomnia: difficulty falling or staying asleep. - Dry mouth: reduced salivation.

Serious or Rare Side Effects: - Serotonin syndrome: agitation, hyperthermia, muscle rigidity. - Severe allergic reaction: rash, swelling, breathing difficulty. - Syncope: sudden fainting episodes. - Cardiac arrhythmia: irregular heart rhythm.

Before prescribing Infirem, clinicians should consider several safety aspects. - Cardiovascular assessment: avoid in uncontrolled hypertension or significant heart disease. - Psychiatric history: use cautiously in patients with depression or anxiety disorders. - Concomitant serotonergic drugs: evaluate risk of serotonin syndrome. - Liver function: dose adjustment may be needed in hepatic impairment. - Alcohol consumption: advise moderation to reduce dizziness risk. - Store at ambient temperature: keep below 25°C, retain in original packaging, protect from moisture.

Dapoxetine can interact with several medication classes, requiring careful management.

Major Interactions (Avoid): - MAO inhibitors: risk of hypertensive crisis and serotonin syndrome. - Other SSRIs or SNRIs: additive serotonergic effect may precipitate serotonin syndrome. - Pimozide: increased plasma levels leading to cardiac toxicity.

Moderate Interactions (Monitor Closely): - CYP2D6 inhibitors (e.g., quinidine, fluoxetine): may raise dapoxetine concentrations. - Alcohol: can enhance dizziness and hypotensive effects.