Infectofos

Fosfomycin, the active ingredient in Infectofos, is an antibacterial presented as an intravenous solution for intravenous use. It is employed to treat serious bacterial infections, including complicated urinary tract infections and severe soft‑tissue infections, and respiratory tract infections in hospitalized patients.

GNH USA supplies Infectofos as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, clinics and procurement teams worldwide, ensuring quality compliance and reliable delivery across multiple markets through.

Fosfomycin is used intravenously to treat infections caused by susceptible bacteria in several organ systems.

Complicated urinary tract infection: eradicates Gram‑negative pathogens causing upper urinary tract infection. Severe skin and soft‑tissue infection: provides bactericidal activity against resistant Staphylococcus aureus. Lower respiratory tract infection: treats hospital‑acquired pneumonia caused by susceptible organisms. Bone and joint infection: aids in the management of osteomyelitis when other agents are limited.

Fosfomycin may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Nausea - Diarrhea - Headache - Infusion site erythema or phlebitis - Elevated liver enzymes - Hypokalemia

Serious or Rare Side Effects: - Anaphylactic shock - Stevens‑Johnson syndrome or toxic epidermal necrolysis - Clostridioides difficile‑associated colitis - Severe hepatic dysfunction - Acute renal failure - Hemolytic anemia

When prescribing intravenous fosfomycin, clinicians should consider several precautionary measures to ensure safe use.

- Renal function: adjust dose in patients with impaired renal clearance. - Electrolyte monitoring: watch for hypokalemia and correct as needed. - Hepatic status: monitor liver enzymes during prolonged therapy. - Concomitant antibiotics: avoid antagonistic combinations that may reduce efficacy. - Pregnancy and lactation: use only if benefits outweigh potential risks. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Fosfomycin can interact with other medicines, altering its effectiveness or increasing toxicity.

Major Interactions (Avoid): - Aminoglycosides: antagonistic effect reducing antibacterial activity. - Warfarin: potentiates anticoagulant effect, may increase INR.

Moderate Interactions (Monitor Closely): - Loop diuretics: may exacerbate electrolyte disturbances, especially hypokalemia. - Insulin or oral hypoglycemics: fosfomycin can enhance hypoglycemic effect. - Other nephrotoxic agents (e.g., vancomycin, NSAIDs): increase risk of renal impairment. - Antacids containing calcium or magnesium: may affect absorption if given orally.