Infectofos

Fosfomycin, the active ingredient in Infectofos, is a phosphonic acid antibiotic presented as a intravenous solution for intravenous use. It treats complicated urinary tract infections, lower respiratory tract infections, and skin and soft tissue infections in adult patients.

GNH USA supplies Infectofos as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Fosfomycin is used to treat bacterial infections affecting specific organ systems.

Complicated urinary tract infections: effective in eradicating Gram‑negative and Gram‑positive pathogens causing upper and lower urinary tract involvement. Lower respiratory tract infections: used to manage bacterial pneumonia and bronchitis when susceptible organisms are identified. Skin and soft tissue infections: employed for cellulitis, wound infections and other soft‑tissue bacterial conditions.

Fosfomycin may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea: mild gastrointestinal upset that often resolves without intervention. - Diarrhea: loose stools occurring during therapy. - Headache: transient cranial discomfort. - Injection site reactions: erythema, pain or swelling at the intravenous site.

Serious or Rare Side Effects: - Hypersensitivity reactions: rash, pruritus, or anaphylaxis requiring immediate medical attention. - Hepatotoxicity: elevated liver enzymes or jaundice in rare cases. - Hematologic abnormalities: neutropenia or thrombocytopenia reported infrequently.

When prescribing fosfomycin, clinicians should consider several precautionary measures to ensure safe use. - Renal function: adjust therapy in patients with severe renal impairment. - Pregnancy: use only if potential benefit outweighs risk, as safety data are limited. - Concomitant nephrotoxic drugs: monitor for additive kidney toxicity. - Electrolyte balance: observe serum potassium and magnesium during prolonged therapy. - Allergies: avoid in individuals with known hypersensitivity to fosfomycin or related compounds. - Store at ambient temperature: keep vials in original packaging, protect from light and moisture, and do not freeze.

Fosfomycin can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): may increase INR, requiring close monitoring. - Live vaccines: concurrent use may reduce vaccine efficacy.

Moderate Interactions (Monitor Closely): - Aminoglycosides: combined nephrotoxicity risk; monitor renal function. - Loop diuretics: may enhance electrolyte disturbances. - Probenecid: can increase fosfomycin plasma concentrations. - Oral contraceptives: potential reduction in effectiveness; advise additional contraceptive measures.