Infectocortikrupp

Prednisolone acetate, the active ingredient in Infectocortikrupp, is a corticosteroid presented as a rectal formulation for rectal use. It provides anti‑inflammatory and immunosuppressive effects for conditions affecting the lower gastrointestinal tract.

GNH USA supplies Infectocortikrupp as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Prednisolone acetate is a corticosteroid that reduces inflammation in the gastrointestinal tract.

- Ulcerative colitis: reduces mucosal inflammation and helps maintain remission in the colon. - Proctitis: alleviates rectal inflammation, decreasing bleeding, urgency and discomfort. - Rectal inflammatory disease: provides localized anti‑inflammatory action to control flare‑ups of lower GI inflammation.

Common Side Effects: - Rectal irritation or burning sensation - Discharge or spotting - Headache - Nausea or mild stomach upset - Increased appetite - Mild insomnia

Serious or Rare Side Effects: - Adrenal suppression or insufficiency - Severe systemic infection - Hyperglycemia or worsening diabetes - Osteoporosis with long‑term use - Cataracts or glaucoma - Anaphylactic or severe allergic reaction

Before initiating therapy, consider the following precautions: - Assess for active infections: avoid use if uncontrolled infection is present. - Monitor blood glucose: patients with diabetes may require dose adjustments. - Evaluate adrenal function: prolonged use can suppress the hypothalamic‑pituitary‑adrenal axis. - Use with caution in patients with hypertension or cardiovascular disease. - Limit duration: avoid long‑term continuous use without medical supervision. - Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Prednisolone acetate may interact with several medicines.

Major Interactions (Avoid): - Systemic CYP3A4 inhibitors (e.g., ketoconazole) – may increase corticosteroid levels. - Systemic CYP3A4 inducers (e.g., rifampicin) – may reduce efficacy. - Live vaccines – risk of uncontrolled infection. - Anticoagulants (e.g., warfarin) – may enhance anticoagulant effect. - NSAIDs – increased risk of gastrointestinal ulceration.

Moderate Interactions (Monitor Closely): - Diuretics – may exacerbate potassium loss. - Antidiabetic agents – may require dose adjustment due to hyperglycemia. - Antihypertensives – possible reduction in blood pressure control.