INDOMETHACIN 50 mg/1

Indomethacin, the active ingredient in INDOMETHACIN 50 mg/1, is a nonsteroidal anti-inflammatory drug (NSAID) presented as a 50 mg suppository for rectal use. It is used to relieve moderate to severe pain, tenderness, swelling, and stiffness caused by various forms of arthritis and other inflammatory conditions. GNH USA supplies INDOMETHACIN 50 mg/1 as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide.

INDOMETHACIN 50 mg/1 is a trusted product for managing inflammatory conditions, ensuring patients receive effective relief from pain and inflammation. GNH USA is committed to providing high-quality pharmaceuticals to meet global healthcare needs.

INDOMETHACIN 50 mg/1 is used to manage pain and inflammation associated with various conditions. It is particularly effective in treating:

- Rheumatoid arthritis: Reduces pain, swelling, and stiffness in the joints. - Ankylosing spondylitis: Alleviates inflammation and pain in the spine. - Osteoarthritis: Helps manage joint pain and inflammation. - Acute gouty arthritis: Provides relief from severe pain and inflammation during gout attacks. - Acute painful shoulder (bursitis and/or tendinitis): Reduces pain and inflammation in the shoulder joint.

INDOMETHACIN 50 mg/1, like other NSAIDs, can cause a range of side effects. Common Side Effects: - Headache - Dizziness - Dyspepsia (indigestion) - Nausea - Serious or Rare Side Effects: - Cardiovascular thrombotic events (e.g., heart attack, stroke) - Gastrointestinal bleeding, ulceration, and perforation - Hepatotoxicity (liver damage) - Hypertension (high blood pressure) - Renal toxicity and hyperkalemia (high potassium levels) - Anaphylactic reactions (severe allergic reactions) - Serious skin reactions (e.g., Stevens-Johnson syndrome)

INDOMETHACIN 50 mg/1 should be used with caution and under medical supervision. Important precautions include: - Avoid use in patients with a history of peptic ulcer disease or gastrointestinal bleeding: Increased risk of bleeding and ulceration. - Monitor patients with preexisting asthma: May exacerbate asthma symptoms. - Use with caution in patients with renal impairment: May worsen kidney function. - Avoid use in patients with a history of proctitis or recent rectal bleeding: May cause further irritation. - Store at 2° to 8°C: Keep refrigerated, protect from light, and do not freeze.

INDOMETHACIN 50 mg/1 can interact with other medications, potentially altering their effects or increasing the risk of side effects. Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): Increased risk of bleeding. - Aspirin: May reduce the anti-inflammatory effects of indomethacin. - ACE inhibitors (e.g., lisinopril): May reduce the antihypertensive effects and increase the risk of kidney damage. - Moderate Interactions (Monitor Closely): - Diuretics (e.g., furosemide): May reduce the diuretic effect and increase the risk of kidney damage. - Methotrexate: Increased risk of methotrexate toxicity. - Lithium: May increase lithium levels, leading to toxicity.