Imurel (Iv)

Azathioprine, the active ingredient in Imurel (Iv), is an immunosuppressant presented as an intravenous solution for intravenous use. It is used to prevent organ transplant rejection and to treat autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, and inflammatory bowel disease.

GNH USA supplies Imurel (Iv) as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, and pharmacies worldwide, ensuring quality and regulatory compliance. The company adheres to stringent quality standards and provides reliable logistics for global distribution.

Azathioprine is employed in clinical practice to modulate immune responses in transplant and autoimmune disease settings.

Organ transplant rejection: helps prevent graft rejection by suppressing lymphocyte proliferation. Rheumatoid arthritis: reduces joint inflammation and disease progression. Systemic lupus erythematosus: diminishes auto‑antibody production and organ damage. Inflammatory bowel disease: controls intestinal inflammation and maintains remission.

Azathioprine may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Nausea or vomiting. - Decreased appetite. - Mild leukopenia or lymphopenia. - Elevated liver enzymes. - Skin rash or itching.

Serious or Rare Side Effects: - Severe bone marrow suppression (pancytopenia). - Hepatotoxicity with jaundice. - Pancreatitis. - Increased susceptibility to infections. - Risk of malignancies such as lymphoma. - Severe hypersensitivity reactions including fever and organ involvement.

Before initiating therapy, clinicians should consider several safety measures.

Monitor blood counts: perform regular CBC to detect bone marrow suppression. Assess liver function: schedule periodic LFTs to identify hepatotoxicity. Avoid in patients with known hypersensitivity to azathioprine or its metabolites. Pregnancy: classified as Category D; use only when benefits outweigh potential fetal risks. Vaccinations: avoid live vaccines while on therapy. Store at ambient temperature: keep in original container, protect from light and moisture.

Azathioprine can interact with other medicines, altering its safety or efficacy.

Major Interactions (Avoid): - Allopurinol: may increase azathioprine toxicity; concurrent use should be avoided. - Warfarin: can enhance anticoagulant effect; monitor INR closely. - Live vaccines: heightened infection risk; avoid administration during treatment.

Moderate Interactions (Monitor Closely): - Concurrent immunosuppressants (e.g., cyclosporine, tacrolimus): may increase bone marrow suppression; monitor blood counts. - Sulfonamide antibiotics: potential additive myelosuppression; observe hematologic parameters.