Imurel

Azathioprine, the active ingredient in Imurel, is an immunosuppressant presented as an oral tablet for oral use. It is employed to reduce immune system activity in patients undergoing organ transplantation, those with rheumatoid arthritis, and individuals with inflammatory bowel disease.

GNH USA supplies Imurel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide, adhering to EU GMP standards and providing reliable global distribution. The company ensures product integrity through rigorous quality control and regulatory compliance.

Azathioprine is used in several immune‑mediated conditions where suppression of lymphocyte activity is required.

- Organ transplantation: helps prevent graft rejection by inhibiting immune response. - Rheumatoid arthritis: reduces joint inflammation and disease progression. - Inflammatory bowel disease: maintains remission in Crohn’s disease and ulcerative colitis.

Azathioprine may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea: mild stomach upset or vomiting. - Fatigue: general tiredness or weakness. - Elevated liver enzymes: mild hepatic irritation detectable in blood tests. - Decreased white blood cell count: mild leukopenia increasing infection risk.

Serious or Rare Side Effects: - Severe bone marrow suppression: pancytopenia requiring medical intervention. - Hepatotoxicity: significant liver injury with jaundice. - Increased risk of infections: opportunistic infections due to immune suppression. - Possible malignancies: rare reports of lymphomas or skin cancers.

When prescribing azathioprine, clinicians should consider several safety precautions to minimize risks. - Baseline testing: obtain complete blood count and liver function tests before initiation. - Monitoring: perform regular CBC and liver enzymes during therapy. - Infection risk: avoid use in patients with active infections. - Pregnancy: assess risk‑benefit; use only if clearly needed. - Drug interactions: review concomitant medications that affect metabolism. - Store at ambient temperature: keep below 25 °C in the original container, protect from moisture.

Azathioprine interacts with several agents that can alter its efficacy or toxicity.

Major Interactions (Avoid): - Allopurinol or febuxostat: markedly increase azathioprine levels, risk of bone marrow suppression. - TPMT inhibitors: can lead to severe myelosuppression.

Moderate Interactions (Monitor Closely): - Warfarin: may enhance anticoagulant effect, monitor INR. - Live vaccines: increased risk of infection, avoid during therapy. - Antacids containing magnesium or aluminum: may reduce absorption, separate dosing.