Imurek I.V.

Azathioprine, the active ingredient in Imurek I.V., is a immunosuppressant (antimetabolite) presented as a sterile injectable solution for intravenous use. It is employed to prevent organ transplant rejection and to manage certain autoimmune diseases in adult patients. GNH USA supplies Imurek I.V. as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and pharmacies worldwide.

Azathioprine is used as an immunosuppressive agent in conditions where modulation of the immune response is required. - Organ transplant rejection: helps prevent acute and chronic rejection of transplanted organs. - Rheumatoid arthritis: reduces joint inflammation and slows disease progression. - Inflammatory bowel disease: maintains remission in Crohn's disease and ulcerative colitis.

Azathioprine may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects: - Nausea or vomiting: gastrointestinal discomfort occurring shortly after infusion. - Decreased appetite: reduced desire to eat, potentially leading to weight loss. - Mild leukopenia: slight reduction in white blood cell count, monitored with routine labs. - Elevated liver enzymes: transient increase in hepatic transaminases.

Serious or Rare Side Effects: - Severe bone marrow suppression: profound leukopenia or pancytopenia requiring medical intervention. - Hepatotoxicity: significant liver injury presenting with jaundice or elevated bilirubin. - Pancreatitis: acute inflammation of the pancreas with abdominal pain and elevated enzymes.

Before initiating therapy, several safety measures should be observed. - Monitor blood counts: perform regular CBC to detect leukopenia early. - Assess liver function: schedule periodic LFTs to identify hepatotoxicity. - Screen for viral infections: test for hepatitis B, C and HIV prior to treatment. - Avoid in known hypersensitivity: discontinue if allergic reactions occur. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Azathioprine interacts with several medicines that can alter its efficacy or safety.

Major Interactions (Avoid): - Allopurinol: markedly increases azathioprine toxicity; concurrent use is contraindicated. - Warfarin: may enhance anticoagulant effect, increasing bleeding risk. - Ribavirin: can potentiate bone marrow suppression.

Moderate Interactions (Monitor Closely): - ACE inhibitors: may increase risk of renal impairment. - NSAIDs: can exacerbate gastrointestinal irritation and affect renal function. - Live vaccines: reduced vaccine efficacy and potential for infection.