Imurek

Azathioprine, the active ingredient in Imurek, is an immunosuppressant presented as an oral tablet for oral use. It is employed to prevent organ transplant rejection and to manage autoimmune disorders such as rheumatoid arthritis and inflammatory bowel disease. GNH USA supplies Imurek as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Azathioprine is used in several immune‑mediated conditions to reduce abnormal immune activity.

Organ transplant rejection: helps prevent the immune system from attacking the transplanted organ. Rheumatoid arthritis: reduces joint inflammation and slows disease progression. Inflammatory bowel disease (Crohn's disease, ulcerative colitis): diminishes intestinal inflammation and supports maintenance of remission.

Azathioprine may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Nausea or vomiting - Decreased appetite - Mild leukopenia or neutropenia - Skin rash or itching - Fatigue or weakness - Mild liver enzyme elevation

Serious or Rare Side Effects: - Severe bone‑marrow suppression (pancytopenia) - Hepatotoxicity or liver failure - Acute pancreatitis - Increased susceptibility to serious infections - Risk of malignancies such as lymphoma - Severe hypersensitivity reactions, including Stevens‑Johnson syndrome

Before initiating therapy, several safety considerations should be observed. - Monitor blood counts: perform regular complete blood count tests to detect bone‑marrow suppression. - Assess liver function: periodic liver enzyme testing is recommended. - Avoid use in active infections: postpone treatment until infections are resolved. - Use caution in renal impairment: dose adjustments may be required. - Adjust dose for elderly patients: start at the lower end of the dosing range. - Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Azathioprine interacts with several medicines that can alter its efficacy or safety.

Major Interactions (Avoid): - Allopurinol or febuxostat: may increase azathioprine toxicity. - Warfarin: azathioprine can enhance anticoagulant effect, raising INR. - Live vaccines: risk of uncontrolled infection due to immunosuppression.

Moderate Interactions (Monitor Closely): - ACE inhibitors: may increase risk of renal dysfunction. - NSAIDs: can aggravate gastrointestinal irritation and affect renal function. - Antacids containing magnesium or aluminum: may reduce azathioprine absorption.