Imuran Mitis

Azathioprine, the active ingredient in Imuran Mitis, is an immunosuppressant presented as an oral tablet for oral use. It is employed to reduce immune system activity in conditions such as organ transplantation, rheumatoid arthritis, inflammatory bowel disease and systemic lupus erythematosus.

GNH USA supplies Imuran Mitis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Azathioprine is used across several immune‑mediated disease categories to modulate overactive lymphocyte activity. - Organ transplantation: helps prevent graft rejection by suppressing immune response. - Rheumatoid arthritis: reduces joint inflammation and slows disease progression. - Inflammatory bowel disease: maintains remission in Crohn’s disease and ulcerative colitis. - Systemic lupus erythematosus: diminishes systemic inflammation and autoantibody production.

Azathioprine may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Nausea or vomiting: gastrointestinal upset occurring shortly after dosing. - Leukopenia: reduced white blood cell count that may increase infection risk. - Elevated liver enzymes: mild hepatic enzyme rise detectable on routine labs.

Serious or Rare Side Effects: - Bone marrow aplasia: profound suppression of blood cell production requiring immediate medical attention. - Severe infections: opportunistic infections due to immunosuppression. - Hepatotoxicity: significant liver injury manifesting as jaundice or hepatitis.

Before initiating therapy, several safety considerations should be addressed. - Blood count monitoring: perform baseline and periodic CBC to detect leukopenia. - Liver function monitoring: assess hepatic enzymes regularly for signs of toxicity. - Pregnancy risk: avoid use in pregnancy (Category D) unless benefits outweigh risks. - Dose adjustment: consider renal or hepatic impairment when determining dose. - Infection vigilance: educate patients to report fever or signs of infection promptly. - Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Azathioprine interacts with several medicines that can alter its efficacy or safety profile.

Major Interactions (Avoid): - Allopurinol: may increase azathioprine toxicity by inhibiting its metabolism. - Warfarin: can enhance anticoagulant effect, raising bleeding risk. - Live vaccines: immunosuppression may lead to uncontrolled infection from the vaccine strain.

Moderate Interactions (Monitor Closely): - NSAIDs: may increase risk of bone marrow suppression. - ACE inhibitors: potential additive effect on renal function. - Sulfonamides and azole antifungals: may interfere with azathioprine metabolism, requiring dose adjustments.