Imuran

Azathioprine, the active ingredient in Imuran, is an immunosuppressant presented as an oral tablet for oral use. It is employed to reduce immune system activity in patients undergoing organ transplantation, those with rheumatoid arthritis, and individuals with inflammatory bowel disease. It is indicated for long‑term management to maintain graft function and control chronic inflammation.

GNH USA supplies Imuran as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and pharmacies worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution.

Azathioprine is used to modulate immune‑mediated conditions by suppressing lymphocyte proliferation.

Organ transplantation: helps prevent graft rejection by inhibiting the immune response. Rheumatoid arthritis: reduces joint inflammation and disease progression. Inflammatory bowel disease: maintains remission in Crohn's disease and ulcerative colitis.

Adverse reactions may vary in frequency and severity.

Common Side Effects: - Nausea or vomiting. - Decreased white blood cell count. - Mild rash or itching.

Serious or Rare Side Effects: - Severe bone marrow suppression causing anemia or infections. - Hepatotoxicity with elevated liver enzymes. - Pancreatitis or severe abdominal pain.

Before and during treatment, several precautions should be observed.

Baseline monitoring: obtain CBC and liver function tests before starting therapy. Infection risk: avoid live vaccines and monitor for signs of infection during treatment. Pregnancy: use only if potential benefit justifies risk; discuss with healthcare provider. Renal/hepatic impairment: dose adjustment may be required; assess organ function regularly. Drug‑specific contraindications: discontinue if severe bone marrow suppression occurs. Store at ambient temperature: keep below 25 °C, protect from moisture and light in original packaging.

Azathioprine may interact with several medicines; some require avoidance while others need close monitoring.

Major Interactions (Avoid): - Allopurinol: may increase azathioprine toxicity. - Warfarin: azathioprine can enhance anticoagulant effect. - Live vaccines: concurrent use may cause severe infection.

Moderate Interactions (Monitor Closely): - Ribavirin: may increase risk of bone marrow suppression. - ACE inhibitors: may affect renal function; monitor laboratory parameters.