Imodium Plus

Dimeticone and Loperamide Hydrochloride, the active ingredient in Imodium Plus, is an antidiarrheal (μ‑opioid receptor agonist) and anti‑foaming agent presented as an oral dosage form for oral use. It treats acute nonspecific diarrhea, travelers’ diarrhea, and provides symptomatic relief of abdominal gas in adults.

GNH USA supplies Imodium Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to stringent quality standards and providing regulatory‑compliant distribution across global markets.

Imodium Plus, containing loperamide and dimeticone, acts on intestinal motility and gas bubbles to manage diarrheal and gas‑related conditions.

- Acute nonspecific diarrhea: reduces stool frequency and improves consistency. - Travelers' diarrhea: provides rapid symptom control for individuals on short‑term trips. - Abdominal gas: dimeticone lowers surface tension of gas bubbles, facilitating relief of bloating and discomfort.

Imodium Plus may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects: - Constipation: reduced bowel movements or hard stools. - Abdominal cramps: mild to moderate discomfort. - Nausea: feeling of queasiness. - Dizziness: light‑headed sensation. - Dry mouth: reduced salivation.

Serious or Rare Side Effects: - Severe constipation or intestinal obstruction: may require medical attention. - Allergic reactions: rash, itching, swelling, or anaphylaxis. - Cardiac arrhythmias: rare QT‑prolongation leading to palpitations. - Toxic megacolon: rare but life‑threatening colonic dilation.

Before using Imodium Plus, consider the following precautions to ensure safe and effective use. - Pregnancy: consult a healthcare professional as safety data are limited. - Breastfeeding: use with caution; limited information on excretion in milk. - Pediatric use: not recommended for children under a specified age without medical advice. - Infectious diarrhea: avoid if diarrhea is caused by bacterial infection or Clostridioides difficile. - Dosage limits: do not exceed the amount recommended by a prescriber or product labeling. - Store at ambient temperature: keep below 25 °C, retain in original packaging, and protect from moisture and direct sunlight.

Imodium Plus can interact with other medicines; awareness of these interactions helps prevent adverse outcomes.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase loperamide plasma levels and risk of cardiac effects. - Other antidiarrheal agents (e.g., diphenoxylate, bismuth subsalicylate): additive slowing of gut motility can cause severe constipation. - QT‑prolonging drugs (e.g., macrolide antibiotics, antiarrhythmics): combined use may heighten risk of arrhythmia.

Moderate Interactions (Monitor Closely): - Opioid analgesics: may enhance central opioid effects and increase sedation. - Anticholinergic medications: can exacerbate constipation. - Moderate CYP3A4 inhibitors (e.g., erythromycin, fluconazole): may modestly raise loperamide concentrations.