Imodium Plus

Loperamide hydrochloride and dimethicone, the active ingredients in Imodium Plus, are an opioid receptor agonist and antiflatulent presented as an oral dosage form for oral use. It reduces diarrhea and relieves gas in adults experiencing acute nonspecific or travel‑related diarrhea and gastrointestinal bloating.

GNH USA supplies Imodium Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Imodium Plus, containing loperamide and dimethicone, acts on the gastrointestinal tract to manage diarrheal disorders and intestinal gas.

- Acute nonspecific diarrhea: provides symptomatic relief by slowing intestinal transit. - Traveler's diarrhea: helps control loose stools during short‑term travel‑related episodes. - Gastrointestinal gas and bloating: reduces gas bubbles and discomfort through the antiflatulent action of dimethicone.

Common Side Effects: - Constipation: reduced bowel movements. - Abdominal cramps: mild stomach discomfort. - Nausea: feeling of queasiness. - Flatulence: increased gas. - Dizziness: light‑headed sensation. - Headache: mild to moderate pain.

Serious or Rare Side Effects: - Severe constipation or bowel obstruction: risk of impaction. - Toxic megacolon: rare but life‑threatening colonic dilation. - Allergic reactions: rash, itching, swelling. - Cardiac arrhythmia: rare QT prolongation. - Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Before using Imodium Plus, consider the following precautions: - Indication limitation: use only for short‑term relief of acute diarrhea. - Infectious diarrhea: avoid if diarrhea is caused by bacterial infection or contains blood. - Liver impairment: exercise caution in patients with hepatic dysfunction. - Drug interactions: monitor use with CYP3A4 or P‑glycoprotein inhibitors. - Pediatric use: not recommended for children under 12 years without medical advice. - Store at ambient temperature: keep in the original container, protect from moisture and heat.

Imodium Plus may interact with other medicines. Review the following:

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may increase loperamide levels. - P‑glycoprotein inhibitors (e.g., quinidine, ritonavir): can raise systemic exposure. - Other antidiarrheal agents: risk of excessive slowing of gut motility.

Moderate Interactions (Monitor Closely): - Anticholinergic drugs: additive constipation. - CNS depressants (e.g., benzodiazepines): may enhance drowsiness. - Calcium channel blockers: possible increased constipation risk.