GNH USA

Europe — EMA

Imodium Duo (Dimeticone, Loperamide Hydrochloride)

GNH USA supplies Imodium Duo (Loperamide Hydrochloride, Dimeticone), a antidiarrheal and antiflatulent for acute diarrhea, travelers' diarrhea, and abdominal

Dimeticone, Loperamide Hydrochloride

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What is Dimeticone, Loperamide Hydrochloride?

Loperamide Hydrochloride and Dimeticone, the active ingredient in Imodium Duo, is a antidiarrheal; antiflatulent presented as Loperamide Hydrochloride 2 mg / Dimeticone 125 mg oral tablet for oral use. It treats acute and travel‑related diarrhea and relieves abdominal bloating and gas in adults.

GNH USA supplies Imodium Duo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Dimeticone, Loperamide Hydrochloride used for?

Imodium Duo, an antidiarrheal and antiflatulent, works on intestinal motility and gas formation.

Acute diarrhea: reduces stool frequency and improves consistency. Travelers' diarrhea: provides rapid symptom control for travelers experiencing sudden loose stools. Abdominal bloating and gas: alleviates discomfort by decreasing gas bubble surface tension.

What are the side effects of Dimeticone, Loperamide Hydrochloride?

Imodium Duo may cause a range of adverse reactions.

Common Side Effects: - Constipation - Abdominal cramps - Nausea - Flatulence - Dizziness - Headache

Serious or Rare Side Effects: - Severe constipation or paralytic ileus - Allergic reactions such as rash or angioedema - Cardiac arrhythmia including QT prolongation - Toxic megacolon or severe colonic dilation - Stevens‑Johnson syndrome or other severe skin reactions

What precautions apply to Dimeticone, Loperamide Hydrochloride?

Before using Imodium Duo, consider the following precautions.

Pregnancy: safety not established; consult a healthcare professional. Age: not recommended for children under 2 years. Underlying infection: avoid in bacterial, parasitic, or C. difficile‑associated diarrhea. Concurrent opioids: may enhance peripheral opioid effects. Dehydration: ensure adequate fluid replacement prior to use. Store at ambient temperature: keep below 25 °C, retain original packaging, protect from moisture.

What does Dimeticone, Loperamide Hydrochloride interact with?

Imodium Duo can interact with other medicines; review the following.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): increase loperamide levels and cardiac risk. - Other antidiarrheal agents (e.g., diphenoxylate): additive gut‑motility suppression. - Opioid analgesics: enhanced peripheral opioid effect.

Moderate Interactions (Monitor Closely): - CYP2C9 inhibitors (e.g., fluconazole): modestly raise loperamide concentrations. - Anticholinergic drugs: may increase constipation. - Antihistamines: may augment drowsiness.

Frequently asked questions

What is Imodium Duo used for?+
Imodium Duo is indicated for the symptomatic relief of acute diarrhea, travelers' diarrhea, and abdominal bloating or gas. It combines an antidiarrheal agent with an antiflatulent to both reduce stool frequency and alleviate discomfort caused by excess intestinal gas.
How does Loperamide Hydrochloride work?+
Loperamide Hydrochloride acts as a peripheral μ‑opioid receptor agonist in the gastrointestinal tract. By binding these receptors, it slows intestinal peristalsis, increases transit time, and reduces fluid secretion, which together help to firm stools and decrease the number of bowel movements.
What is the usual dose of Imodium Duo?+
The dosage of Imodium Duo is determined by the prescribing healthcare professional based on the individual’s condition, age, and response. OTC labeling typically provides general guidance, but the exact regimen should always follow the prescriber’s instructions.
Is Imodium Duo safe in pregnancy or breastfeeding?+
Safety data for Imodium Duo in pregnancy and lactation are limited. The product’s pregnancy category is unknown, so it should only be used if the potential benefit justifies the potential risk. Women who are pregnant or breastfeeding should consult their healthcare provider before use.
How do I order Imodium Duo from GNH USA?+
To order Imodium Duo, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.
How does Imodium Duo compare with other antidiarrheal options?+
Compared with standard loperamide‑only products, Imodium Duo adds dimeticone, which specifically targets gas‑related bloating. This dual action can provide broader symptom relief for patients who experience both loose stools and abdominal distension, whereas single‑ingredient loperamide addresses only stool frequency.
How should Imodium Duo be stored and handled?+
Imodium Duo tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original blister pack or container, protect from moisture and direct sunlight, and keep out of reach of children.
How is Imodium Duo administered?+
Imodium Duo is taken orally as a tablet with a glass of water. It may be taken with or without food, according to the prescriber’s advice. Swallow the tablet whole; do not crush or chew it.
What are the most serious risks to watch for while using Imodium Duo?+
Serious risks include severe constipation, paralytic ileus, toxic megacolon, and cardiac arrhythmias such as QT prolongation. If any of these symptoms occur—marked abdominal pain, inability to pass stool or gas, fainting, or irregular heartbeat—seek medical attention immediately.
Who should not use Imodium Duo?+
Imodium Duo should be avoided in children younger than 2 years, in patients with known hypersensitivity to loperamide or dimeticone, and in individuals with infectious diarrhea caused by bacteria, parasites, or Clostridioides difficile. It is also contraindicated in patients with severe hepatic impairment.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Dimeticone, Loperamide Hydrochloride
Route
Oral Use
Manufacturer
Kenvue Netherlands B.V.
Origin
EU

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