Immex

Loperamide Hydrochloride, the active ingredient in Immex, is a peripheral opioid agonist presented as an oral dosage form for oral use. It is employed to reduce intestinal motility and fluid secretion, helping manage diarrhea in adults.

GNH USA supplies Immex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for global healthcare providers. Immex is manufactured under EU GMP guidelines and distributed through GNH USA's regulated supply chain.

Loperamide Hydrochloride is used to treat diarrheal disorders by slowing intestinal transit.

- Acute nonspecific diarrhea: reduces stool frequency and improves consistency. - Chronic diarrhea: provides symptomatic relief by decreasing bowel movements. - Irritable bowel syndrome with diarrhea (IBS‑D): alleviates diarrhea‑predominant symptoms and improves quality of life.

Loperamide Hydrochloride may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Constipation - Abdominal cramps - Nausea - Dizziness - Dry mouth - Flatulence

Serious or Rare Side Effects: - Severe constipation or intestinal obstruction - Toxic megacolon - Allergic reactions such as rash, itching, or swelling - Cardiac arrhythmias, including QT prolongation - Ileus - Severe abdominal pain

When prescribing Loperamide Hydrochloride, clinicians should consider several safety measures to minimize risk.

- Assess dehydration: ensure patient is adequately rehydrated before use. - Avoid infectious diarrhea: do not use in cases of bacterial enteritis or Clostridioides difficile infection. - Do not exceed recommended dose: follow prescriber instructions to prevent toxicity. - Use with caution in hepatic impairment: reduced metabolism may increase systemic exposure. - Avoid in children under 2 years: safety not established. - Store at room temperature: keep in original container, protect from moisture and light.

Loperamide Hydrochloride can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid): - CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): increase plasma levels and risk of cardiac toxicity. - CYP2C8 inhibitors (e.g., gemfibrozil): raise systemic exposure and potential adverse effects. - Other opioid agonists (e.g., codeine, morphine): additive central opioid effects may occur.

Moderate Interactions (Monitor Closely): - Anticholinergic agents (e.g., diphenhydramine): may enhance constipation. - Other antidiarrheal agents (e.g., bismuth subsalicylate): risk of excessive slowing of gut motility. - Drugs that prolong QT interval (e.g., macrolide antibiotics): may increase risk of arrhythmia when combined.