Imdur

Isosorbide Mononitrate, the active ingredient in Imdur, is a nitrate presented as an oral tablet for oral use. It is employed for the prophylaxis of angina pectoris in adult patients who require long‑term reduction of myocardial oxygen demand. This medication belongs to the anti‑anginal therapeutic class and works by providing sustained nitric‑oxide release to dilate coronary vessels.

GNH USA supplies Imdur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Isosorbide Mononitrate is an anti‑anginal nitrate used in the management of coronary artery disease.

- Stable angina: reduces the frequency of chest pain episodes. - Exercise‑induced angina: improves tolerance to physical activity. - Chronic angina pectoris: helps prevent ischemic attacks during daily life.

Isosorbide Mononitrate may cause a range of adverse reactions, most of which are dose‑related and reversible.

Common Side Effects: - Headache: mild to moderate, often transient. - Dizziness or light‑headedness: related to blood pressure changes. - Flushing: warm sensation of skin, especially face. - Nausea or abdominal discomfort. - Palpitations: sensation of rapid or irregular heartbeat. - Hypotension: mild drop in blood pressure.

Serious or Rare Side Effects: - Severe hypotension leading to syncope. - Acute myocardial infarction (rare). - Life‑threatening arrhythmias. - Anaphylactic or severe allergic reactions. - Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Persistent tachycardia unresponsive to therapy.

Before initiating therapy, clinicians should evaluate cardiovascular status and consider patient‑specific factors.

- Assess cardiovascular stability: ensure patient is not hypotensive before dosing. - Avoid abrupt discontinuation: taper to prevent rebound angina. - Use caution with other nitrates: risk of additive hypotension. - Monitor blood pressure regularly during dose adjustments. - Adjust dose in renal impairment: consider reduced clearance. - Store at below 25°C: keep in the original pack, protect from moisture.

Isosorbide Mononitrate can interact with several drug classes, requiring careful management.

Major Interactions (Avoid): - Other nitrates (e.g., nitroglycerin, isosorbide dinitrate): may cause profound hypotension. - Phosphodiesterase‑5 inhibitors (e.g., sildenafil, tadalafil): risk of severe blood pressure drop.

Moderate Interactions (Monitor Closely): - Antihypertensive agents (ACE inhibitors, beta‑blockers, calcium channel blockers): additive blood pressure lowering. - Diuretics: may enhance orthostatic hypotension. - Alcohol: can increase vasodilatory effects and dizziness.