Imdur

Isosorbide Mononitrate, the active ingredient in Imdur, is a nitrate vasodilator presented as an oral tablet for oral use. It is employed to prevent episodes of angina pectoris in patients with coronary artery disease.

GNH USA supplies Imdur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Imdur, a nitrate vasodilator, is used in the management of coronary artery disease‑related chest pain. - Angina pectoris (stable): reduces the frequency of chest pain episodes. - Exercise‑induced angina: improves tolerance to physical activity. - Prevention of angina attacks: maintains symptom control during daily life.

Common Side Effects: - Headache: often transient and dose‑related. - Dizziness or light‑headedness: due to vasodilation. - Flushing: warm sensation of skin. - Nausea or upset stomach. - Palpitations: awareness of heartbeat. - Low blood pressure (orthostatic): may cause faintness.

Serious or Rare Side Effects: - Severe hypotension: marked drop in blood pressure requiring medical attention. - Syncope: sudden loss of consciousness. - Myocardial infarction (rare): chest pain worsening. - Allergic reactions: rash, itching, swelling. - Stevens‑Johnson syndrome or toxic epidermal necrolysis: severe skin reactions.

Before initiating therapy, consider the following precautions. - Dose titration: start with a low dose and increase gradually as tolerated. - Concomitant PDE‑5 inhibitors: avoid due to risk of profound hypotension. - Blood pressure monitoring: watch for symptomatic drops. - Renal or hepatic impairment: assess function and adjust if needed. - Pregnancy and lactation: use only if clearly indicated after risk‑benefit evaluation. - Store at ambient temperature: keep below 25 °C, protect from moisture and keep in original packaging.

Isosorbide mononitrate may interact with several drug classes. Major Interactions (Avoid): - Phosphodiesterase‑5 inhibitors (e.g., sildenafil): can cause severe hypotension. - Other nitrates (e.g., nitroglycerin, isosorbide dinitrate): additive vasodilatory effect. Moderate Interactions (Monitor Closely): - Antihypertensives (ACE inhibitors, beta‑blockers): may enhance blood‑pressure lowering. - Diuretics: increase risk of dehydration and hypotension. - Alcohol: can potentiate vasodilatory response and dizziness.