Imdur

Isosorbide mononitrate, the active ingredient in Imdur, is a nitrate presented as an oral tablet for oral use. It is indicated for the prophylaxis and treatment of chronic stable angina pectoris in adult patients, helping to reduce the frequency of angina attacks and improve exercise tolerance.

GNH USA supplies Imdur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with European Union marketing authorisation requirements and is manufactured under GMP conditions. It is distributed to a broad network of healthcare providers across multiple continents.

Imdur (isosorbide mononitrate) is used in the management of coronary artery disease and related angina syndromes.

Prophylaxis of angina pectoris: reduces the frequency of angina episodes by providing sustained nitrate‑mediated vasodilation. Treatment of chronic stable angina: improves exercise tolerance and decreases the need for short‑acting nitrates during daily activities. Prevention of exertional angina: maintains myocardial oxygen balance during physical stress, helping patients remain active.

Isosorbide mononitrate may cause a range of adverse reactions, varying in frequency and severity.

Common Side Effects: - Headache: throbbing pain often occurring early in therapy. - Dizziness: sensation of light‑headedness, especially on standing. - Flushing: warmth and redness of the face or neck. - Nausea: upset stomach with possible mild vomiting.

Serious or Rare Side Effects: - Severe hypotension: marked blood pressure fall leading to syncope. - Syncope: sudden loss of consciousness. - Allergic reaction: rash, itching, swelling, or breathing difficulty.

When prescribing isosorbide mononitrate, clinicians should observe several precautionary measures to ensure safe use.

- Assess cardiovascular status: evaluate baseline blood pressure and heart rate before initiation. - Avoid concurrent PDE‑5 inhibitors: co‑administration can cause profound hypotension. - Monitor for tolerance development: efficacy may diminish over time, requiring dose reassessment. - Use with caution in hepatic impairment: reduced metabolism may increase drug exposure. - Pregnancy category B: discuss potential risks and benefits with the prescriber. - Store at ambient temperature: keep in the original container, protect from moisture and light.

Isosorbide mononitrate can interact with several medicines, altering its effect or safety profile.

Major Interactions (Avoid): - Sildenafil and other PDE‑5 inhibitors: may cause severe hypotension. - Other nitrates (e.g., nitroglycerin): additive vasodilatory effect leading to dangerous blood pressure drops. - Antihypertensive agents (ACE inhibitors, beta‑blockers, calcium channel blockers): can enhance blood pressure‑lowering actions.

Moderate Interactions (Monitor Closely): - Alcohol: can increase hypotensive effect. - Diuretics: may potentiate blood pressure reduction. - Azole antifungals (e.g., ketoconazole): may raise plasma concentrations of isosorbide mononitrate.