Imdur

Isosorbide Mononitrate, the active ingredient in Imdur, is a nitrate presented as an oral tablet for oral use. It is employed to prevent angina pectoris in patients with coronary artery disease. GNH USA supplies Imdur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Imdur belongs to the nitrate class and is used in the management of coronary artery disease‑related chest pain. - Angina pectoris (stable): reduces the frequency and severity of chest pain episodes. - Chronic stable angina: improves exercise tolerance by decreasing myocardial oxygen demand. - Ischemic heart disease: helps prevent angina attacks during physical or emotional stress.

Imdur may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects: - Headache: throbbing pain often occurring shortly after the first dose. - Dizziness or light‑headedness, especially when standing quickly. - Flushing: warm sensation and reddening of the skin. - Nausea or mild gastrointestinal discomfort. - Palpitations or rapid heartbeat.

Serious or Rare Side Effects: - Severe hypotension leading to fainting or shock. - Syncope (sudden loss of consciousness). - Allergic reactions such as rash, itching, or swelling of the face and throat. - Methemoglobinemia, a rare blood disorder causing reduced oxygen delivery.

Before initiating Imdur, several safety considerations should be reviewed. - Discontinuation: avoid abrupt stopping to prevent rebound angina. - Hypotension: use cautiously in patients with low blood pressure or volume depletion. - Hepatic impairment: dose adjustment may be required in severe liver disease. - Concomitant PDE‑5 inhibitors: increased risk of profound hypotension; avoid co‑administration. - Pregnancy: safety not established; prescribe only if potential benefit outweighs risk. - Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Isosorbide mononitrate can interact with several drug classes, altering its safety profile.

Major Interactions (Avoid): - Other nitrates (e.g., nitroglycerin): additive vasodilatory effect may cause severe hypotension. - Phosphodiesterase‑5 inhibitors (e.g., sildenafil, tadalafil): risk of profound blood pressure drop.

Moderate Interactions (Monitor Closely): - Antihypertensive agents (e.g., ACE inhibitors, beta‑blockers): may enhance blood‑pressure‑lowering effect. - Diuretics: can increase the likelihood of orthostatic hypotension. - Alcohol: may potentiate vasodilatory side effects such as dizziness and flushing.