Imdur

Isosorbide Mononitrate, the active ingredient in Imdur, is an organic nitrate presented as an oral tablet for oral use. It is used to prevent and treat episodes of angina pectoris in adults who require long‑term anti‑anginal therapy.

GNH USA supplies Imdur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Imdur belongs to the organic nitrate class and is employed in the management of coronary artery disease‑related chest pain. - Chronic stable angina: reduces the frequency and severity of angina attacks. - Exercise‑induced angina: improves tolerance to physical activity. - Angina prophylaxis: maintains symptom control during daily activities.

Isosorbide mononitrate may cause a range of adverse reactions, most of which are dose‑related and reversible.

Common Side Effects: - Headache: throbbing or pressure sensation. - Dizziness or light‑headedness, especially on standing. - Flushing: warmth and redness of the face or neck. - Nausea or mild gastrointestinal upset. - Palpitations: awareness of heartbeat.

Serious or Rare Side Effects: - Severe hypotension: marked drop in blood pressure causing fainting. - Methemoglobinemia: reduced oxygen‑carrying capacity of blood. - Allergic reactions: rash, itching, swelling, or difficulty breathing. - Chest pain worsening: paradoxical increase in angina. - Syncope: sudden loss of consciousness.

Before initiating therapy with Imdur, consider the following safety measures. - Concomitant nitrate use: avoid combined use with other nitrates to prevent severe hypotension. - Phosphodiesterase‑5 inhibitors: do not co‑administer with sildenafil, tadalafil, or vardenafil. - Cardiovascular status: monitor patients with unstable heart disease closely. - Renal or hepatic impairment: dose adjustment may be required based on clinical judgment. - Pregnancy and lactation: use only if the potential benefit justifies the potential risk. - Store at ambient temperature: keep below 25 °C, retain in the original container, and protect from moisture.

Isosorbide mononitrate can interact with several drug classes, influencing its efficacy or safety.

Major Interactions (Avoid): - Other organic nitrates or nitroglycerin: additive vasodilatory effect leading to profound hypotension. - Phosphodiesterase‑5 inhibitors: risk of severe blood pressure fall.

Moderate Interactions (Monitor Closely): - Antihypertensive agents (e.g., ACE inhibitors, beta‑blockers): may enhance blood pressure‑lowering effect. - Diuretics: can increase the risk of orthostatic hypotension. - Alcohol: may potentiate vasodilatory side effects. - Certain antacids: may affect absorption if taken simultaneously.