Imdur

Isosorbide 5-Mononitrate, the active ingredient in Imdur, is an organic nitrate presented as an oral tablet for oral use. It is employed for the prophylaxis of angina pectoris in adults, helping to reduce the frequency of chest pain episodes by lowering myocardial oxygen demand.

GNH USA supplies Imdur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Imdur belongs to the organic nitrate class and is used to manage angina‑related conditions. - Stable angina pectoris: reduces the frequency of chest pain attacks during daily activities. - Exercise‑induced angina: helps prevent pain triggered by physical exertion. - Effort angina: provides prophylactic relief for pain that occurs with sustained effort.

Isosorbide 5‑Mononitrate may cause a range of adverse reactions.

Common Side Effects: - Headache: mild to moderate, often transient. - Flushing: warm sensation with reddening of skin. - Dizziness: especially upon standing quickly. - Nausea: occasional gastrointestinal upset. - Hypotension: mild drop in blood pressure. - Palpitations: awareness of heartbeat.

Serious or Rare Side Effects: - Severe hypotension: marked blood pressure fall requiring medical attention. - Syncope: fainting episodes. - Methemoglobinemia: rare discoloration of blood. - Allergic reactions: rash, itching, or swelling. - Chest pain worsening: paradoxical increase in angina. - Liver enzyme elevation: abnormal liver function tests.

Before initiating therapy, consider the following precautions. - Concomitant nitrate therapy: avoid simultaneous use to prevent severe hypotension. - Phosphodiesterase‑5 inhibitors: do not combine with drugs like sildenafil due to risk of profound blood pressure drop. - Cardiovascular instability: use cautiously in patients with recent myocardial infarction or unstable angina. - Renal impairment: dose adjustment may be required in severe renal dysfunction. - Pregnancy: safety not established; avoid unless clearly needed. - Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Isosorbide 5‑Mononitrate can interact with several medication classes.

Major Interactions (Avoid): - Other organic nitrates: additive vasodilatory effect leading to severe hypotension. - Phosphodiesterase‑5 inhibitors: risk of dangerous blood pressure reduction. - Antihypertensive agents: may cause excessive blood pressure lowering.

Moderate Interactions (Monitor Closely): - Diuretics: may enhance hypotensive response. - Beta‑blockers: combined effect on heart rate and blood pressure. - Calcium channel blockers: additive vasodilatory action. - Alcohol: can increase dizziness and hypotension. - Certain antibiotics (e.g., macrolides): may affect metabolism and plasma levels.