Imdur

Isosorbide 5-Mononitrate, the active ingredient in Imdur, is a nitrate vasodilator presented as an oral tablet for oral use. It is employed to relieve angina pectoris and chronic stable angina by improving myocardial oxygen supply in adult patients.

GNH USA supplies Imdur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with consistent quality and regulatory compliance. Our distribution network ensures timely delivery across Europe, Asia and the Americas. We adhere to stringent GMP standards and provide full documentation for regulatory submissions.

Isosorbide 5-Mononitrate is a nitrate vasodilator used in the management of coronary artery disease. - Angina pectoris: reduces the frequency and severity of chest pain episodes. - Chronic stable angina: improves exercise tolerance and delays onset of angina. - Prophylaxis of angina attacks: provides sustained nitrate release to prevent episodic angina.

Isosorbide 5-Mononitrate may cause a range of adverse reactions.

Common Side Effects: - Headache: throbbing pain often occurring shortly after dosing. - Dizziness or light‑headedness: related to blood pressure reduction. - Flushing: warm sensation and reddening of the skin. - Hypotension: measurable drop in blood pressure, especially when standing. - Nausea: mild gastrointestinal upset. - Palpitations: awareness of heartbeat irregularities.

Serious or Rare Side Effects: - Severe hypotension: marked blood pressure fall requiring medical attention. - Syncope: sudden loss of consciousness. - Myocardial infarction: rare but possible in susceptible patients. - Allergic reactions: rash, itching, or swelling. - Methemoglobinemia: rare blood disorder causing cyanosis. - Life‑threatening arrhythmias: extremely uncommon but serious.

Before initiating therapy, clinicians should consider several safety measures. - Cardiovascular assessment: evaluate baseline blood pressure and heart rate. - Blood pressure monitoring: check regularly, especially after dose changes. - Concomitant nitrate use: avoid combining with other nitrate preparations. - Phosphodiesterase‑5 inhibitors: do not co‑administer with sildenafil, tadalafil, or similar agents. - Patient counseling: advise on rising slowly from sitting or lying positions to reduce orthostatic symptoms. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Isosorbide 5-Mononitrate can interact with several drug classes.

Major Interactions (Avoid): - Phosphodiesterase‑5 inhibitors (e.g., sildenafil, tadalafil): risk of profound hypotension. - Other nitrates (e.g., nitroglycerin, isosorbide dinitrate): additive vasodilatory effect. - Guanylate cyclase stimulators: excessive vasodilation.

Moderate Interactions (Monitor Closely): - Antihypertensive agents (ACE inhibitors, ARBs, beta‑blockers): may enhance blood pressure lowering. - Diuretics: potential for volume depletion and hypotension. - Calcium channel blockers: monitor for additive cardiovascular effects. - Oral contraceptives: may alter nitrate metabolism, requiring observation.