Imdur

Isosorbide 5‑mononitrate, the active ingredient in Imdur, is a nitrate class medication presented as an extended‑release tablet for oral administration. It is indicated for the prophylactic treatment of angina pectoris, helping to reduce the frequency of chest pain episodes in patients with documented coronary artery disease.

GNH USA supplies Imdur as a licensed, Good Distribution Practice‑compliant pharmaceutical product, providing reliable access to hospitals, pharmacies and clinics worldwide through its international supply network. The product complies with EU regulatory standards and is manufactured under strict quality controls.

Imdur (isosorbide 5‑mononitrate) is an anti‑anginal nitrate used in the management of coronary artery disease.

- Stable angina: reduces the frequency of chest pain episodes. - Exercise‑induced angina: improves tolerance to physical activity. - Chronic coronary syndrome: helps prevent myocardial ischemia during daily activities.

Imdur is generally well tolerated, but several adverse reactions have been reported.

Common Side Effects: - Headache: mild to moderate, often transient. - Flushing: warmth and redness of the skin. - Dizziness or light‑headedness. - Hypotension: especially when standing. - Nausea or abdominal discomfort. - Palpitations or tachycardia.

Serious or Rare Side Effects: - Severe hypotension leading to syncope. - Allergic reactions such as rash, itching, or angioedema. - Methemoglobinemia: rare but potentially serious. - Chest pain worsening on abrupt discontinuation. - Life‑threatening hypotensive crisis when combined with other vasodilators.

Before prescribing Imdur, clinicians should consider several safety aspects.

- Abrupt discontinuation: may precipitate rebound angina; tapering is recommended. - Monitor blood pressure: risk of symptomatic hypotension, especially in the elderly. - Hepatic impairment: use with caution in severe liver disease. - Concomitant PDE‑5 inhibitors: avoid due to risk of profound hypotension. - Pregnancy and lactation: safety not established; use only if benefit outweighs potential risk. - Store at ambient temperature: keep in the original pack, protect from moisture and light.

Imdur can interact with several drug classes, requiring attention to dosing and monitoring.

Major Interactions (Avoid): - Phosphodiesterase‑5 inhibitors (e.g., sildenafil): may cause severe hypotension. - Other nitrates (e.g., nitroglycerin, isosorbide dinitrate): additive vasodilatory effect. - Alcohol: can enhance hypotensive response.

Moderate Interactions (Monitor Closely): - Antihypertensives (ACE inhibitors, beta‑blockers): may increase blood pressure‑lowering effect. - Diuretics: may potentiate orthostatic hypotension. - Azole antifungals (e.g., ketoconazole): may raise plasma levels of isosorbide 5‑mononitrate.