Imasup

Azathioprine, the active ingredient in Imasup, is an immunosuppressant presented as an oral formulation for oral use. It is employed to prevent organ transplant rejection and to treat several autoimmune conditions, including rheumatoid arthritis and inflammatory bowel disease, in adult patients.

GNH USA supplies Imasup as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Azathioprine is used across immune‑mediated conditions and transplant medicine to reduce pathological immune activity.

Organ transplant rejection: helps maintain graft viability by suppressing immune‑mediated attack. Rheumatoid arthritis: reduces joint inflammation and slows disease progression. Inflammatory bowel disease (Crohn's disease, ulcerative colitis): diminishes intestinal inflammation and maintains remission.

Azathioprine may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Nausea or vomiting - Decreased white blood cell count (leukopenia) - Elevated liver enzymes - Mild rash or itching

Serious or Rare Side Effects: - Severe bone marrow suppression leading to pancytopenia - Hepatotoxicity with jaundice or hepatic failure - Increased risk of opportunistic infections and certain malignancies

Before initiating therapy, clinicians should evaluate baseline laboratory values and monitor patients regularly.

Baseline blood count: obtain complete blood count and liver function tests. Infection risk: screen for latent viral infections (e.g., hepatitis B, TB). Pregnancy considerations: assess risks versus benefits; avoid unless clearly indicated. Drug monitoring: adjust dose based on TPMT enzyme activity when available. Store below 25°C: keep in the original pack, protect from moisture.

Azathioprine interacts with several medicines that can alter its efficacy or toxicity.

Major Interactions (Avoid): - Allopurinol or febuxostat: may cause severe bone marrow suppression. - Live vaccines: increased risk of infection due to immunosuppression.

Moderate Interactions (Monitor Closely): - Warfarin: may enhance anticoagulant effect, requiring INR monitoring. - Ribavirin: can increase hematologic toxicity. - Antacids containing magnesium or aluminum: may reduce azathioprine absorption.