Iloprost Zentiva

Iloprost, the active ingredient in Iloprost Zentiva, is a prostacyclin analog presented as an intravenous solution for intravenous administration. Marketed in the European Union, it is used to treat pulmonary arterial hypertension and to improve healing of digital ulcers in patients with systemic sclerosis.

GNH USA supplies Iloprost Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide, providing quality‑assured product and regulatory support for global distribution through reliable and timely established logistics networks.

Iloprost is a prostacyclin analog used in the management of vascular disorders affecting the pulmonary circulation and peripheral digital vessels.

Pulmonary arterial hypertension: reduces pulmonary vascular resistance and improves exercise capacity. Digital ulcers associated with systemic sclerosis: promotes ulcer healing and reduces the formation of new ulcers.

Adverse reactions may occur with Iloprost therapy.

Common Side Effects: - Headache: mild to moderate intensity. - Flushing: transient warmth and redness. - Nausea: occasional gastrointestinal upset. - Jaw pain: discomfort during chewing. - Diarrhea: loose stools. - Hypotension: mild blood pressure drop.

Serious or Rare Side Effects: - Pulmonary edema: fluid accumulation in lungs. - Severe hypotension: marked blood pressure reduction. - Bleeding: increased risk of hemorrhage. - Thrombocytopenia: low platelet count. - Arrhythmia: irregular heart rhythm. - Anaphylaxis: severe allergic reaction.

Iloprost requires careful monitoring and specific handling precautions.

Monitor blood pressure: watch for hypotension during infusion. Assess bleeding risk: avoid in patients with active hemorrhage. Evaluate hepatic function: adjust use if liver impairment is present. Use caution in heart failure: may exacerbate fluid overload. Avoid concurrent vasodilators: risk of additive hypotensive effect. Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Iloprost can interact with several drug classes, necessitating vigilance.

Major Interactions (Avoid): - Other prostacyclin analogs: additive vasodilation. - Potent CYP2C9 inhibitors: increased plasma levels. - Anticoagulants (e.g., warfarin): heightened bleeding risk. - Endothelin receptor antagonists: excessive hypotension.

Moderate Interactions (Monitor Closely): - Nitrates: monitor for synergistic blood pressure effects. - Calcium channel blockers: observe for enhanced vasodilatory response. - Diuretics: watch for electrolyte disturbances. - ACE inhibitors: assess for additive hypotension.