Iloprost Zentiva

Iloprost, the active ingredient in Iloprost Zentiva, is a prostacyclin analog presented as an inhalation solution for inhalation use. It provides vasodilation and inhibits platelet aggregation, helping to lower pulmonary arterial pressure in adult patients with pulmonary arterial hypertension.

GNH USA supplies Iloprost Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides regulatory documentation to facilitate import and clinical use across multiple regions.

Iloprost is a prostacyclin analog used in the management of pulmonary arterial hypertension, a disease characterized by elevated pulmonary vascular resistance.

- Pulmonary arterial hypertension: improves exercise capacity and delays disease progression. - Chronic thromboembolic pulmonary hypertension: provides vasodilation to improve hemodynamics. - Pulmonary hypertension secondary to interstitial lung disease: helps reduce pulmonary artery pressure.

Iloprost may cause a range of adverse reactions, which are generally categorized by frequency and severity.

Common Side Effects: - Cough: irritation of the airways leading to coughing episodes. - Headache: mild to moderate headache often occurring after inhalation. - Flushing: warmth and redness of the face or neck. - Nausea: feeling of stomach upset or urge to vomit.

Serious or Rare Side Effects: - Pulmonary edema: accumulation of fluid in the lungs requiring medical attention. - Severe hypotension: marked drop in blood pressure that may cause dizziness or fainting. - Thrombocytopenia: significant reduction in platelet count increasing bleeding risk.

When prescribing Iloprost, clinicians should consider several precautionary measures to ensure safe use.

- Monitor blood pressure: check for hypotension after each dose. - Assess bleeding risk: avoid use in patients with active bleeding or severe thrombocytopenia. - Evaluate pulmonary function: use cautiously in patients with severe lung disease. - Pregnancy and lactation: safety not established; weigh benefits against potential risks. - Drug interactions: review concomitant vasodilators and anticoagulants. - Store at room temperature: keep in original container, protect from moisture and light.

Iloprost can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid): - Combined use with other potent vasodilators: may cause severe hypotension. - Concurrent anticoagulants (e.g., warfarin, heparin): increased risk of bleeding. - Phosphodiesterase‑5 inhibitors (e.g., sildenafil): additive pulmonary vasodilation leading to hypotension.

Moderate Interactions (Monitor Closely): - Aspirin or other antiplatelet agents: may enhance antiplatelet effect. - Calcium channel blockers: possible additive blood pressure lowering. - Nicorandil: overlapping vasodilatory mechanisms.