GNH USA

Europe — EMA

Iloprost Zentiva

GNH USA supplies Iloprost Zentiva (Iloprost), a prostacyclin analog for pulmonary arterial hypertension. Request a quote for global supply worldwide.

Iloprost

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What is Iloprost?

Iloprost, the active ingredient in Iloprost Zentiva, is a prostacyclin analog presented as an inhalation solution for nebulization use. It treats pulmonary arterial hypertension in adult patients by improving vascular tone and exercise capacity.

GNH USA supplies Iloprost Zentiva as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

What is Iloprost used for?

Iloprost acts on the prostacyclin pathway to manage pulmonary vascular disease.

Pulmonary arterial hypertension: improves exercise capacity and delays disease progression. Chronic thromboembolic pulmonary hypertension: used as adjunct therapy to improve hemodynamics. Digital ulcers in systemic sclerosis: may promote ulcer healing and reduce pain.

What are the side effects of Iloprost?

Common Side Effects: - Cough or throat irritation during inhalation - Headache - Flushing or warmth sensation - Nausea or dyspepsia

Serious or Rare Side Effects: - Significant hypotension or syncope - Pulmonary edema - Severe bronchospasm or respiratory distress - Bleeding complications, including hemoptysis

What precautions apply to Iloprost?

Patients receiving Iloprost should be monitored closely for cardiovascular and respiratory safety.

Monitor blood pressure: watch for hypotension after inhalation. Assess bleeding risk: avoid in patients with active hemorrhage or on strong anticoagulants. Evaluate liver function: adjust use if hepatic impairment is present. Avoid use in recent myocardial infarction: defer therapy for at least 30 days post‑event. Store at room temperature: keep in original container, protect from moisture and light.

What does Iloprost interact with?

Iloprost may interact with other agents that affect vascular tone or platelet function.

Major Interactions (Avoid): - Concurrent use of potent vasodilators (e.g., nitroglycerin) may cause severe hypotension. - Strong anticoagulants (e.g., warfarin) increase risk of bleeding. - Phosphodiesterase‑5 inhibitors combined with high‑dose Iloprost may amplify vasodilatory effects.

Moderate Interactions (Monitor Closely): - Aspirin or other antiplatelet drugs: monitor for bleeding. - Other pulmonary arterial hypertension therapies (e.g., endothelin receptor antagonists): adjust dosing as needed. - Smoking or nicotine products: may reduce drug efficacy.

Frequently asked questions

What is Iloprost Zentiva used for?+
Iloprost Zentiva is an inhaled prostacyclin analogue indicated for the treatment of pulmonary arterial hypertension (PAH). By delivering the drug directly to the lungs, it helps to dilate the pulmonary arteries, improve blood flow, and increase exercise capacity in adult patients with PAH. It may also be employed as adjunct therapy in related pulmonary vascular conditions.
How does Iloprost work?+
Iloprost mimics the natural prostacyclin molecule and binds to IP receptors on pulmonary vascular smooth‑muscle cells. This activates adenylate cyclase, raising intracellular cyclic AMP levels, which causes vasodilation, inhibits platelet aggregation, and suppresses smooth‑muscle proliferation. The combined actions reduce pulmonary arterial pressure and improve oxygen delivery.
What is the usual dose of Iloprost Zentiva?+
The exact dosing regimen for Iloprost Zentiva is individualized by the prescribing physician based on disease severity, response, and tolerability. In clinical practice the inhalation solution is commonly administered 2 to 6 times per day, with each session lasting a few minutes using a certified nebulizer. Patients should follow the specific instructions provided by their healthcare professional.
Is Iloprost safe in pregnancy or breastfeeding?+
Safety data for Iloprost during pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss risks with their physician.
How do I order Iloprost Zentiva from GNH USA?+
To place an order, submit an enquiry on the Iloprost Zentiva product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.
How does Iloprost compare with other PAH treatments?+
Iloprost is an inhaled prostacyclin analogue, offering targeted pulmonary delivery and rapid onset, whereas agents such as epoprostenol are administered intravenously and treprostinil can be given subcutaneously, orally, or inhaled. Compared with oral endothelin receptor antagonists, Iloprost provides direct vasodilation but requires patient‑operated nebulization, making it suitable for patients who prefer inhaled therapy or need combination treatment.
What are the storage and handling requirements for Iloprost Zentiva?+
The inhalation solution should be stored at room temperature, preferably below 25 °C, in its original sealed container. Protect the product from moisture, direct sunlight and extreme temperatures. Do not freeze the solution, and keep it out of reach of children. Once opened, use according to the manufacturer’s stability guidelines.
How is Iloprost Zentiva administered?+
Iloprost Zentiva is supplied as a sterile solution for nebulization. The patient uses a compatible ultrasonic or jet nebulizer, inhaling the mist over a few minutes. Dosing frequency and duration are prescribed by the clinician. Proper cleaning of the nebulizer device and adherence to inhalation technique are essential for optimal drug delivery.
What are the most serious risks to watch for while using Iloprost Zentiva?+
The most critical adverse events include marked hypotension, which can lead to dizziness or syncope, severe bronchospasm causing respiratory distress, pulmonary edema, and bleeding complications such as hemoptysis. Patients should be educated to seek immediate medical attention if they experience sudden shortness of breath, chest pain, or unexplained bleeding.
Who should not use Iloprost Zentiva?+
Iloprost is contraindicated in individuals with known hypersensitivity to iloprost or any component of the formulation. It should also be avoided in patients with severe hypotension, recent myocardial infarction (within the past 30 days), active uncontrolled bleeding, or severe pulmonary infection. Clinicians must assess each patient’s medical history before initiating therapy.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Iloprost
Route
Inhalation Use
Manufacturer
Zentiva Italia S.R.L.
Origin
EU

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