Iloprost Zentiva

Iloprost, the active ingredient in Iloprost Zentiva, is a prostacyclin analog presented as an inhalation solution for inhalation use. It is indicated for the treatment of pulmonary arterial hypertension and for the management of digital ulcers associated with systemic sclerosis in adult patients.

GNH USA supplies Iloprost Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing products sourced from the EU market under strict quality standards and supporting regulatory compliance for importers.

Iloprost acts on the prostacyclin pathway to provide vasodilatory and antiplatelet effects in pulmonary vascular disease.

Pulmonary arterial hypertension: improves exercise capacity and delays disease progression. Digital ulcers associated with systemic sclerosis: promotes ulcer healing and reduces new ulcer formation.

Iloprost may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects: - Cough: mild to moderate irritation of the airways. - Headache: transient, often resolves with continued therapy. - Flushing: warmth and redness of the skin. - Nausea: occasional gastrointestinal upset. - Throat irritation: discomfort during inhalation. - Dizziness: light‑headed sensation, usually transient.

Serious or Rare Side Effects: - Pulmonary edema: fluid accumulation in the lungs requiring immediate care. - Severe hypotension: marked drop in blood pressure that may cause fainting. - Bleeding: increased risk due to platelet inhibition. - Thrombocytopenia: low platelet count, potentially leading to bruising. - Allergic reactions: rash, itching, or anaphylaxis. - Chest pain: may indicate cardiac ischemia and needs urgent evaluation.

When using Iloprost, several precautionary measures should be observed to ensure safety and efficacy.

Dose titration: adjust according to patient tolerance and clinical response. Monitoring: regularly assess blood pressure and pulmonary function. Contraindications: avoid in patients with severe left‑heart disease. Pregnancy: use only if potential benefit justifies risk to fetus. Drug interactions: review concomitant medications for potential interactions. Store at room temperature: keep in original container, protect from light and moisture.

Iloprost can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid): - Anticoagulants: increased risk of bleeding. - Epoprostenol: additive vasodilatory effect leading to severe hypotension. - Sildenafil: potentiation of pulmonary vasodilation may cause hypotension.

Moderate Interactions (Monitor Closely): - Warfarin: may require INR monitoring. - Bosentan: possible additive effect on pulmonary pressure. - Calcium channel blockers: monitor blood pressure for additive hypotensive effect.